PARK8 is Cloned: Introducing…"Dardarin"
Biochemists, cell and molecular biologists, start your engines! You now have another Parkinson protein challenge...
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IDE—Levels Up, But Activity Down, in Amyloid-Burdened Vasculature
Because insulin degrading enzyme (IDE) also degrades Aβ (as well as the AβPP intracellular domain), it has come under intense scrutiny in AD research...
San Diego: HIV and AD—Save the Body, Lose the Mind?
Drug cocktails have transformed HIV infection from a deadly to a chronic disease, giving HIV carriers a new lease on life. But new long-term consequences...
San Diego: HLA and γ-Secretase? A Curiosity Now, But Just You Wait…
Venturing off the beaten path, <strong>Bryce Carey</strong> yesterday presented a poster at the Society for Neuroscience meeting about the interaction...
San Diego: Too Much APP Blocks Transport, Starves Down's Neurons
Which genes are responsible for the known phenomenon that cholinergic neurons in Alzheimer disease and Down syndrome die because they can’t get their daily fix of nerve growth factor?...
An AD Gene Nugget on Chromosome 12?
Leaders of a multinational team of researchers report that a gene encoding glyderaldehyde-3-phosphate dehydrogenase (GAPD) on chromosome 12 is...
ACAT and Mouse—Inhibiting Former Prevents AD-like Pathology in Latter
Inhibiting ACAT, a cholesterol-modifying enzyme, may prove a viable therapy for preventing or slowing the progression of Alzheimer disease...
Tau Kinase Clears Microtubules—Keeps Axonal Transport on Track
Microtubule affinity regulating kinases (MARKs) regulate transport along axonal microtubules by pulling microtubule-associated proteins, including tau, off the tracks...
Caught in the Act—Amyloid Damages Neurons
Since Alois Alzheimer’s first descriptions of senile plaques, we have known that they are associated with dementia. But are they detrimental?...
New Microscope Resolves Role of Huntington Inclusions—Neuroprotection
Inclusion bodies: Grim reapers or guardian angels? A robotic microscope, which can monitor the health of hundreds of neurons infected with mutant huntingtin, has the answer...
DJ Chaperones α-Synuclein—Offers Cell Model of Parkinson Disease
New evidence suggests that DJ-1, which is mutated in some cases of early-onset Parkinson disease, acts as a chaperone that prevents aggregation of...
American Neurological Association: 2004 Annual Meeting
End of the Road for GDNF Parkinson Therapy—or Just a Detour? American Neurological Association: 2004 Annual Meeting
End of the Road for GDNF Parkinson Therapy—or Just a Detour?
Infusing GDNF directly into the striatum of Parkinson disease patients fails to prevent functional decline...
Neuron Refreshes Our Memory
A special section in the September 30 Neuron reviews some of the advances made in understanding the processes involved in learning, storing, and recollecting information...
Remote Healing by Stem Cell-Derived GDNF?
Recent reports suggest that human umbilical cord blood cells can rescue brain neurons damaged by stroke. But curiously, the blood cells don’t have to enter the brain to be effective...
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