Merck Withdraws Vioxx®
Pharmaceutical giant Merck announced today that it was withdrawing rofecoxib, a pain and antiinflammatory drug, from worldwide markets...
ALL NEWS
6538 RESULTS
Sort By:
- Most Recent
- Most Commented
PPARγ Partner PGC-1α Linked to Huntington Disease-Like Symptoms
PPARγ has received a lot of attention from neuroscientists lately. Now, ablation of one of its partners, PGC-1α, has been found to cause...
FRETting Pays off—NSAIDs Target Presenilins, Reduce Aβ42
Some NSAIDs have been shown to shift Aβ production to the shorter Aβ1-38. Now, results suggest that they do this by eliciting a conformational change in presenilin...
Researchers Catch GIT1 in Huntingtin Fishing Net
Researchers demonstrate the power of combining cDNA and yeast two-hybrid (Y2H) screens in pursuit of protein accomplices of disease-suspect molecules, in this case...
Neurobiology of Aging to Publish Negative Results—Call for Manuscripts
Paul Coleman, as editor-in-chief of Neurobiology of Aging, has initiated a policy of accepting negative results for publication...
Protofibrils Permeabilize Lipid Membranes
How are protofibrils toxic? An accelerated publication suggests that they permeabilize and increase the flux of ions across lipid bilayers...
Amyloid Formation—Taking Things One Monomer at a Time
Amyloids are composed of long polymeric fibrils that stick together like glue. But how are the fibers formed?...
Chromosome 5 Is in the Bag
In the September 16 issue of Nature, another legion of geneticists, this one led by Jeremy Schmutz of the Stanford Human Genome Centre in California, pulls the curtain back on a chromosome: number 5...
Focus on Aβ Fibrils: Targeting β-sheets and Foiling Them
Two papers from the past week take aim at the β-sheet structure of proteins prone to pathological aggregation...
Move Over, Mitochondria—Make Room for ER-Induced Cell Death
Mitochondria are a major source of the reactive oxygen species (ROS) that may play a role in neurodegeneration. Now evidence suggests that ROS generated in the endoplasmic reticulum may also lead to cell death...
Want Plaque Protection? Try the X Factors…
…X11, that is, a nuclear adaptor protein that binds to the intracellular domain of amyloid-β precursor protein (AβPP)...
Can Sonic Hedgehog Rejuvenate Parkinson Disease Neurons?
A study in the September issue of Molecular Therapy reports that the developmental regulatory factors Sonic hedgehog (Shh) and Gli-1, but not Nurr-1, can protect dopaminergic neurons...
Fish Oil Swims Ahead in Dietary Brain Protection Race
Organism-level experimental data now lend some support to the epidemiologic evidence that the fatty acids in fish oil can protect against Alzheimer disease...
Neurons Found Marching to the Beat of the Glial Drum
A new study suggests that neurotransmitters from astrocytes can induce synchronous electrical currents in hippocampal neurons…
Increased Neurogenesis in AD? Evidence from APP Mice Strengthens Case
An article in PNAS reports evidence of increased neurogenesis in an animal model of Alzheimer disease that supports results obtained from humans...
Current Filters
No filters selected