Baited BRET—Measuring Ubiquitination/Deubiquitination in Real Time
Researchers studying the ubiquitination pathway may be interested in a new technique that can measure ubiquitination—and deubiquitination—in real time...
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Rifampicin for Parkinson Disease?
Various antibiotics have been shown to protect against neurodegenerative diseases, not necessarily through antimicrobial action. Can one of them, rifampicin, prevent the formation of α-synuclein aggregates?...
Society for Neuroscience Annual Meeting 2004
San Diego: Too Much APP Blocks Transport, Starves Down's Neurons San Diego: HLA and γ-Secretase? A Curiosity Now, But Just You Wait… San Diego: HIV and AD—Save the Body, Lose the Mind? San Diego: Uncouplers Keep Mitochondria Burning Clean—Protect Neu
CSF Proteomics Test for ALS?
Surveying the protein profile of a tissue or body fluid by traditional methods has not proven a very efficient way to detect changes in protein levels in neurodegenerative diseases...
San Diego: AβPP—Can the Tail Wag the Dog?
Since the discovery that one peptide, amyloid-β, is the major constituent of amyloid plaques, there has been a tremendous focus on the N-terminal end of amyloid-β precursor protein...
On-Demand Dendritic Proteins Served Up with Help of Fragile X Protein
Fragile X mental retardation, the most common form of inherited mental impairment, is caused by mutations in the fmr-1 gene, coding for fragile X mental retardation protein...
Light SPARKs Neuronal Action Potentials
Imagine being able to turn on and off an individual neuron remotely—without prodding it with electrodes or challenging it with chemicals. Sound like a neuroscientist's dream?...
Fighting the SUMO Pathway—Implications for Huntington Disease
Defeating the yokozuna, the highest ranked professional sumo wrestlers, is almost impossible. Stopping sumoylation, the modification of proteins with small ubiquitin-like modifiers (SUMO) may be easier...
Study Links Metabolic Syndrome, Inflammation to Cognitive Decline
The metabolic syndrome—a constellation of cardiovascular and diabetes risk factors—is associated with an increased risk of cognitive decline...
Controlling Tau—Phosphatases and Proteases PACK a Punch
Phosphorylation of the microtubule-associated protein tau may be a good thing because it can speed up microtubule transport, but abnormal phosphorylation...
Microscopy Shifts to the Fast Lane with "Cytological Profiling"
Television shows about medical examiners and psychological profilers are all the rage these days. Wouldn't you like to see one about “cytological” profilers?...
Hushing the Mouse that Roared—Elan Mayo Patent Dispute Settled
As many of our readers are aware, there has been a running court battle between Elan Inc., Dublin, Ireland, and the Mayo Foundation for Medical Education and Research...
A Step Toward Therapeutic RNA Interference
An important RNA interference (RNAi) milestone was reported today in Nature...
Adult Corticospinal Neurogenesis—Axons Run Spinal Cord Marathon
Ever since mammalian adult neurogenesis was confirmed, scientists had hoped to get pluripotent cells of the subventricular zone (SVZ) to become...
San Diego: ApoE Effects Explored
Studies on ApoE have exploded since it was discovered that those carrying one copy of ApoE4 allele are more likely to get the disease than...
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