San Diego: AβPP—Can the Tail Wag the Dog?
Since the discovery that one peptide, amyloid-β, is the major constituent of amyloid plaques, there has been a tremendous focus on the N-terminal end of amyloid-β precursor protein...
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On-Demand Dendritic Proteins Served Up with Help of Fragile X Protein
Fragile X mental retardation, the most common form of inherited mental impairment, is caused by mutations in the fmr-1 gene, coding for fragile X mental retardation protein...
Light SPARKs Neuronal Action Potentials
Imagine being able to turn on and off an individual neuron remotely—without prodding it with electrodes or challenging it with chemicals. Sound like a neuroscientist's dream?...
Fighting the SUMO Pathway—Implications for Huntington Disease
Defeating the yokozuna, the highest ranked professional sumo wrestlers, is almost impossible. Stopping sumoylation, the modification of proteins with small ubiquitin-like modifiers (SUMO) may be easier...
Study Links Metabolic Syndrome, Inflammation to Cognitive Decline
The metabolic syndrome—a constellation of cardiovascular and diabetes risk factors—is associated with an increased risk of cognitive decline...
Controlling Tau—Phosphatases and Proteases PACK a Punch
Phosphorylation of the microtubule-associated protein tau may be a good thing because it can speed up microtubule transport, but abnormal phosphorylation...
Microscopy Shifts to the Fast Lane with "Cytological Profiling"
Television shows about medical examiners and psychological profilers are all the rage these days. Wouldn't you like to see one about “cytological” profilers?...
Hushing the Mouse that Roared—Elan Mayo Patent Dispute Settled
As many of our readers are aware, there has been a running court battle between Elan Inc., Dublin, Ireland, and the Mayo Foundation for Medical Education and Research...
A Step Toward Therapeutic RNA Interference
An important RNA interference (RNAi) milestone was reported today in Nature...
Adult Corticospinal Neurogenesis—Axons Run Spinal Cord Marathon
Ever since mammalian adult neurogenesis was confirmed, scientists had hoped to get pluripotent cells of the subventricular zone (SVZ) to become...
San Diego: ApoE Effects Explored
Studies on ApoE have exploded since it was discovered that those carrying one copy of ApoE4 allele are more likely to get the disease than...
San Diego: γ-Secretase Takes Scientists on a Wild Ride
The more scientists learn about γ-secretase, the crazier it looks to them...
Busting up Plaques—Small Molecules Aided by Protein Heavies
If your plaque-busting molecule is too small to prevent amyloid formation, have it bring along a bigger buddy...
San Diego: Treating Forgetfulness—Triple Transgenics Provoke
A mouse model that mimics both signature pathologies of Alzheimer disease develops a day-to-day forgetfulness at four months...
San Diego: Uncouplers Keep Mitochondria Burning Clean—Protect Neurons
Next time you ponder the pros and cons of coal burning power plants, consider this: Mitochondria, our cellular power plants, do a great job keeping us supplied with ATP, but they, too, have emission problems...
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