Not Just a Family Affair: Dardarin Mutations Predict Sporadic PD
In last October’s Neuron, researchers revealed that the gene LRRK2, encoding a protein kinase dubbed “dardarin,” is one and the same with...
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Poles Apart—The Tau Kinase GSK3β Separates Axons and Dendrites
Light and gravity ensure that tree trunks grow straight up while their roots burrow deep underground. What about neurons?...
Statins Boost α-Secretase, but Not Through Cholesterol
In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes...
Lactam Antibiotics Can Prevent Glutamate Neurotoxicity
You <em>can</em> have too much of a good thing. Glutamate, for example, is one of the major excitatory neurotransmitters, but too much of it....
Taxols for Tauopathies?
Taxols, drugs that are commonly used to treat cancer, may offer some therapeutic benefit for patients suffering from Alzheimer disease...
Some Antipsychotic Drugs Impair Glucose Metabolism
A report reinforces earlier observations that some antipsychotic drugs may increase the risk for, or even cause, diabetes in patients with schizophrenia...
Parkin Adversary Is BAGged
Mutations in parkin can cause familial Parkinson disease, but how normal parkin may contribute, if at all, to non-familial PD is more of a mystery...
“Natural” Aβ Oligomers Cause Transitory Cognitive Disruptions
A paper published online 19 December in Nature Neuroscience takes aim at two omnipresent issues in Alzheimer disease research...
Safety Concerns Halt ADAPT Trial
With safety concerns about celecoxib and now naproxen, the Alzheimer's Disease Antiinflammatory Prevention Trial has ground to a halt...
Neurobiology of Aging 2004
Conformation Rules Part 1: News, Common Threads, Debate from San Diego Conference Conformation Rules Part 2: News, Common Threads, Debate from San Diego Protein Misfolding Conference Conformation Rules Part 3: News, Common Threads, Debate from San Diego P
Curry Ingredient Spices Things Up by Blocking Aβ Aggregation
The curry spice curcumin is a potent antioxidant and has been investigated by Greg Cole's team at the University of California, Los Angeles, for possible protective roles in Alzheimer disease...
Conformation Rules Part 3: News, Common Threads, Debate from San Diego Protein Misfolding Conference
This third and final meeting report is continued from the previous day's reports, <a href="/news/conference-coverage/conformation-rules-part-1-news-common-threads-debate-san-diego-conference">Part 1</a> and <a href="/news/conference-coverage/conformation-rules-part-2-news-common-threads-debate-san-diego-protein">Part 2</a>.
Cementing γ-Secretase at the Cell Surface
Researchers report further evidence placing the mature γ-secretase complex at the cell surface, and implicating it in...
Conformation Rules Part 2: News, Common Threads, Debate from San Diego Protein Misfolding Conference
This second meeting report is continued from <a href="/news/conference-coverage/conformation-rules-part-1-news-common-threads-debate-san-diego-conference">Part 1</a>...
Conformation Rules Part 1: News, Common Threads, Debate from San Diego Conference
This is the first section of a report on a protein misfolding meeting, which will be posted in three parts; Part 2 will appear on 17 December, and Part 3 on 20 December 2004...
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