Growing Pains, Mystery Elixir, Mouse Taint—New Spins on Stem Cells
Scientists still have a long way to go before they can harness the immense potential of human stem cells...
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There’s Something FISHy About Aβ Toxicity
When molecular biologists go “fishing,” they don’t really expect to catch any fish. Not unless you’re talking about...
Perinatal Soup—Early Pathogen or Toxin Exposures Leave Brain Vulnerable
Scientists have little trouble accepting the idea that ontogeny is a process rich in interplay between genetic and environmental factors...
Salubrinal to the Rescue? New Compound Fights ER Stress
Researchers at Harvard Medical School report that they have identified a small molecule that interferes with a protein phosphatase in such a way that...
PD Models: Loss of DJ Throws D2 Dopamine Receptor Out of Step
Whenever a genetic cause is found for a disease, an animal model is in the cards, and Parkinson disease (PD) is no exception...
PD Models II: Nature versus Nurture
Just how good are animal models of neurodegenerative disorders? After all, those based on genetic lesions...
Polyglutamine, Inclusion Bodies and the Proteasome—The Good, the Bad, and the Innocent?
Are inclusion bodies the fault of the proteasome? Two groups come up with different answers...
"Bio-Barcode" Amplifies Aβ Oligomer Signal, Proffers Candidate Diagnostic Test
By amplifying small quantities of Aβ oligomer in cerebrospinal fluid, a methodology referred to as the "bio-barcode" could serve as a diagnostic or monitoring test for AD...
Spigot Closed on Industry Consulting for NIH Scientists
Yesterday the National Institutes of Health announced sweeping new rules restricting...
Window to the Brain Shows Dystrophic Neurites Shrinking
Combining their individual fortés, researchers treat us to the sight of neurons being "healed" before our eyes...
Par-4—Not a Long Shot to BACE
Par-4, the leucine-zipper protein first found in apoptotic prostate cancer cells, can regulate β-secretase (BACE) cleavage of amyloid-β precursor protein (AβPP)...
Alzheimer Research Consortium Symposium: Aiming for Mechanism-Based Models of AD
Summary by <a href="/scientific-advisory-board">Peter Davies</a>, Albert Einstein College of Medicine. July 2004, Philadelphia...
Safety Concerns over Galantamine; Fallout from Rofecoxib Debacle Grows
Last Friday, the pharmaceutical company Johnson & Johnson announced that health authorities were reviewing safety data on galantamine hydrobromide...
Aph1A KO Stalls Embryo Development, Supports γ-Secretase Variance
As the γ-secretase complex has given up some of its secrets, it has created new puzzles to solve, such as...
Photons Light up Neuronal Circuits, Pinpoint Single Cells
Using two-photon microscopy, researchers at Harvard Medical School have peered into the brains of rats and cats to see real-time images...
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