Risk Gene Conspiracy: Clusterin Binds CD33, Souring Microglial Taste for Aβ
Clusterin latches onto dimers of CD33 on the microglial cell surface, setting off inhibitory signaling that squelched phagocytosis.
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Clusterin latches onto dimers of CD33 on the microglial cell surface, setting off inhibitory signaling that squelched phagocytosis.
At AD/PD, scientists placed more AD genes into microglial pathways, homed in on how TREM2 gets cleaved, debuted TREM2 agonists, and unearthed potential biomarkers.
At AD/PD, scientists showed 3- and 4-year amyloid immunotherapy data hinting at sustained cognitive benefits. The number of remaining participants is tiny.
Clearance triggers improvement in downstream markers of inflammation and neurodegeneration—but not in those who started with high tangle burden. (Clue: women.)
Envelope proteins from endogenous retroviruses help shuttle tau seeds between cells. Could HERVs fuel tauopathies?
Perivascular macrophages both produce and react to the apolipoprotein, releasing toxic reactive oxygen species that constrict blood vessels.
Inclusions in tau seed sensor cells are made of amyloid fibrils, say scientists at AD/PD 2023. In those cells, and in human neurons, a dis-aggregase shreds them.
Biogen/IONIS’s tau ASO BIIB080 dropped participants’ tau PET signal below baseline in six months of treatment, according to data from a Phase 1 study presented at AD/PD.
Pumping Up Progranulin: Scientists Show New Efforts to Get it Done First Hit on Aggregated Tau: Antisense Oligonucleotide Lowers Tangles Tau Chimeras Do Make Fibrils—and a Chaperone Rips Them Apart Macrophages Blamed for Vascular Trouble in ApoE4 Carriers
Queen Sylvia of Sweden traveled to Gothenburg to welcome scientists to AD/PD. At the conference, the buzz was on about approaches to double levels of the lysosomal protein in FTD.
Anti-amyloid therapy could compromise brain health, a meta-analysis claims. Others say the concern is overblown.
NPTX2 binds complement C1q, disrupting signals to microglia to destroy synapses.
Authors say the evidence that physical activity improves cognition in healthy people is inconclusive. Others disagree.
Single-nucleus RNA-Seq of human brain finds regional differences in endothelial cell subtypes. Transcriptomes change in the presence of plaque or vascular amyloid.
Volunteers who practiced daily slow-breathing exercises for a month lowered Aβ42 in their blood; could this diminish the risk of AD?
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