New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
An antibody copying the effects of the protective ApoE variant prevents tau hyperphosphorylation in the mouse eye and brain.
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Cracking the Cholesterol-AD Code: Metabolites and Cell Type
A cholesterol metabolite magnifies pathology in a tauopathy mouse. Microglia need cholesterol to rein in amyloid. ApoE4 jams the fat's export from neuron to glia.
Does the Brain Use Microglia to Maintain Its Myelin?
We all know oligodendrocytes maintain myelin. According to scientists at the 2nd Symposium on Lipids in Diseases, they need microglia to do it.
Cutting (or Slippery?) Edge: Lipids in Neurodegeneration Science
At a conference on lipids in the brain, scientists reported how unsaturated fatty acids might worsen or ameliorate the effects of proteinopathies.
2nd Symposium on Lipids in Brain Diseases
Cutting (or Slippery?) Edge: Lipids in Neurodegeneration Science Does the Brain Use Microglia to Maintain Its Myelin? Cracking the Cholesterol-AD Code: Metabolites and Cell Type Can Flipping a Lipid Switch Protect the Brain? The average human brain contai
After a Decade, Amyloid PET Scans Receive Broad Insurance Coverage
CMS has lifted restrictions that allowed beneficiaries one scan per lifetime as part of a clinical study. Approval of immunotherapies was a key factor.
Tauopathy Transcriptomes Tell Tantalizing Tales
A comparative snRNA-Seq study of three regions from AD, PSP, and FTD brains identifies subtypes of neurons and glia hit hard in each disorder.
In Alzheimer’s, Tau Oligomers in Synapses Act as ‘Eat Me’ Signal
The oligomers beckon microglia and astrocytes to prune dendrites. This correlates with cognitive decline.
Plasma Proteomics Studies Link Genetic Variants to Phenotypes
A consortium of pharma companies mined data from 50,000 people in the U.K. Biobank to turn up thousands of new gene-protein connections.
Behold, the Human Brain Like Never Seen Before
Reported in 21 papers, a collaborative effort describes brain-wide gene expression, epigenetics, morphology, and activity at single-cell resolution.
Stunning Detail: Single-Cell Studies Chart Genomic Architecture of AD
Resilient and vulnerable interneurons mark different stages of Alzheimer's. Gene regulation crumbles in late stages. Microglial states change with epigenomic shifts.
Could a Faulty Ubiquitin Trigger Amyloid and Tau Deposits?
In human three-dimensional brain cell cultures, UBB+1 caused plaques and tangles. Silencing UBB+1 prevented spontaneous amyloid pathology caused by AD mutations.
Acetylation Accelerates Aggregation of 3R, but Not 4R, Tau
Acetylation of lysine residues unique to 4R tau hinders protofibril folding. The findings might explain selective 3R tau deposition in Pick’s disease.
Not So Fast—The Brain Has Three Meningeal Membranes After All
Using live imaging, electron microscopy, and gene expression studies, two groups show that a purported fourth membrane is instead the inner layer of the arachnoid mater.
Does Plaque ApoE Summon Microglia to Amyloid?
In mice, microglia that sprout vascular cell adhesion molecule 1 flock to amyloid aggregates. ApoE is required.
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