Wanted: Fluid Biomarkers for CAA, ARIA
The ability to quickly detect cerebral amyloid angiopathy and ARIA would make amyloid immunotherapy safer, but research in this area is just beginning.
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Is ARIA an Inflammatory Reaction to Vascular Amyloid?
Scientists at AAIC said ARIA-E resembles inflammation related to cerebral amyloid angiopathy. The prime suspect? The complement cascade.
Spying on α-Synuclein Inclusions: PET Tracers Inch Closer to Success
A crop of new PET tracers that bind α-synuclein aggregates shows promise in tissue samples and in animal models. Will they prove potent enough for brain imaging?
Cohort LEADS Toward Better Understanding of Sporadic Early Onset AD
First data from the Longitudinal Early-Onset Alzheimer’s Disease Study hints at what might cause this type of AD and how it unfolds.
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s Pathology in the Brain?
In mice, curbing a hepatic hydrolase boosted protective epoxy fatty acids in the brain, which stimulated microglia to clear amyloid.
CSF MTBR-tau-243 Tracks Tangles, Plummets in Response to Antibody
In contrast to phospho-tau species that mirror amyloid, CSF MTBR-tau-243 reflects tau-PET. It fell upon treatment with an antibody against tau’s midsection.
Give BACE Inhibitors a Second Chance?
Between basic researchers and clinicians, momentum is growing to test BACE inhibition again. This time, at low doses.
Donanemab Data Anchors Upbeat AAIC
Alzheimer’s researchers got their first look at data from the positive Phase 3 trial. Many expect this antibody to become the third approved immunotherapy for AD.
Alzheimer's Association International Conference (AAIC)- 2023
Donanemab Data Anchors Upbeat AAIC Give BACE Inhibitors a Second Chance? CSF MTBR-tau-243 Tracks Tangles, Plummets in Response to Antibody Cohort LEADS Toward Better Understanding of Sporadic Early Onset AD Spying on α-Synuclein Inclusions: PET Tracers In
Proteomics Discerns Sporadic from Familial Alzheimer’s Disease
While each disease features distinct proteomes in the brain, cerebrospinal fluid, and blood, some proteins overlap. They are more dysregulated in familial than in sporadic AD.
Too Basic: APP β-CTF's YENTPY Motif Binds Proton Pump, Thwarts Lysosomes
In cells from people with Down’s syndrome, and in mouse models of DS and Alzheimer’s, excess β-CTF binds vacuolar ATPase, hobbling lysosomal acidification.
CRISPR Screens Net Tau Partners in Human Neurons, Brain
Two interference screens netted a thousand proteins that affect tau oligomerization. The affected pathways? Mitochondrial malfunction, and UFMylation.
Potential CSF Biomarkers Detect Roused Microglia in AD, FTD
The panel of six marker candidates includes proteins involved in lipid processing and metabolism in microglia.
When Missense Variants Derail SORL1 Traffic, Destination Is Dementia
A trio of studies report that missense variants in SORL1 that disrupt its trafficking or dimerization are highly likely to cause Alzheimer's disease in carriers, strengthening the case for SORL1 being a familial AD gene.
Hundreds of SORL1 Variants Mapped in Alzforum Database; SORL1 Cast as Causal AD Gene
The endocytic receptor SORL1 has come to fruition both literally and figuratively. An interactive diagram of the 2,214 amino acid behemoth—filled with findings about hundreds of rare variants—is live for viewing on the Alzforum Mutations database. A handf
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