Serum NfL Detects Preclinical AD, Reflects Clinical Benefit
The neurodegeneration marker appears to track disease severity in AD and MS patients with great sensitivity.
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Data from DIAN Revise Familiar Biomarker Trajectories
Rather than changing one by one, many biomarkers—including cognition, tau PET, hippocampal atrophy, and CSF p-tau—shift together, around the time of symptom onset in young adults with familial AD.
CRISPR Edits Genome of Human Embryos
CRISPR-Cas9 gene editing rids embryos of a mutation causing heart disease, evoking a future where autosomal-dominant disease is prevented at the DNA level. What about AD, FTD, and ALS?
DIAN’s Tightrope Act: Sharing Data While Protecting Your Wish Not to Know
As data pours in, DIAN leaders strive to share and publish it without accidentally disclosing mutation status. The more is learned about preclinical AD, the harder this may get.
Monogenetic and Sporadic Alzheimer’s Disease: Same or Different?
Armed with what they consider comprehensive data sets from the DIAN initiative, researchers are beginning a quest to settle an old question that may become key to drug approvals for late-onset AD.
Brain Imaging in DIAN: Atrophy Rates—Check. Tau PET—Not Yet.
At AAIC, updated imaging data in autosomal-dominant AD shows that longitudinal MRI in large numbers of people confirms atrophy patterns. Tau PET is more variable in DIAN participants than in the Colombian families.
DIAN Longitudinal Data Say Cognition Goes Earlier Than Previously Thought
Serial measurements on hundreds of people in the Dominantly Inherited Alzheimer’s Network put proposed staging diagrams on an empirical footing. CSF markers sTREM2 and VILIP-1 track tau.
At Age 8, DIAN Is Churning Out Data and Growing into a Movement
At AAIC, 28 scientific presentations and five attendant meetings of the Dominantly Inherited Alzheimer’s Network showed how data is rolling in while the platform expands to more countries and a second therapeutic trial.
New Data on Autosomal-Dominant Alzheimer’s Point to Early Fissures in the Brain’s Microarchitecture
Tiny injuries to capillaries in white matter, and to cells in gray matter, have come to be the focus of new imaging measures being explored in early presymptomatic AD.
Families Challenge DIAN Scientists to Do Even More, Faster
Regulatory and pharma scientists fielded pleas from families with autosomal-dominant Alzheimer’s disease just prior to the AAIC conference.
At DIAN Family Meeting, Funding News Caps Talk of Inadequate Services
Bypass budget promises tide may be turning on an underfunded disease as families with autosomal-dominant Alzheimer’s discuss how to navigate their daily challenges.
100 DIAN Family Members Gather for Their First International Meeting
A sense of shared purpose energized a day of exchange between families with autosomal-dominant AD and researchers engaged in the Dominantly Inherited Alzheimer Network.
Familial Alzheimer’s Gene Alters Children’s Brains
In children as young as 9 who carry a presenilin 1 mutation, researchers detect subtle functional and structural brain changes.
‘Still Alice’ Gives Voice to Patients with Early Onset Alzheimer’s
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
API Biomarker Data Mirror DIAN’s, Support Progression Models
Cross-sectional biomarker data from the Colombian kindred confirm models of biomarker progression, but suggest an earlier drop in brain metabolism.
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