APP Double Dose Causes Early Onset AD
For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus...
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Looking outside the Brain for Early Signs of AD
The use of gene expression profiling to characterize Alzheimer disease pathology has, unsurprisingly, focused on...
All in the Family: Alois Alzheimer’s Second Patient Came from Extended Disease Pedigree
During his lifetime, Alois Alzheimer described five cases of the “characteristic sickness of the cerebral cortex” that his boss, the eminent psychiatrist Emil Kraepelin, later would name in honor of his late colleague. Now, neurologists in Alzheimer’s home state of Bavaria are investigating how these early patients’ family members fared. One patient, Johann F., turns out to have belonged to a large clan afflicted with an early-onset, heritable form of the disease. Many descendants still live in Bavaria, some in the U.S.
Clues from the Colombian Countryside
An enormous extended family living in a rural community in Colombia could provide new insights into environmental and genetic factors contributing to Alzheimer’s disease. All family members who were diagnosed...
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