Colombian Cohort Delivers Data on Blood NfL
In 2,144 Colombian ADAD family members, plasma NfL in gene carriers rises as early as two decades before their symptoms start.
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Crenezumab Update: Baseline Data from Colombian Prevention Trial
At AAIC, researchers presented baseline data from an ongoing, five-year study asking whether the anti-Aβ antibody crenezumab can forestall cognitive decline in autosomal-dominant Alzheimer’s disease.
DIAD: Families from Argentina, Canada, Minnesota Rally a Global Community
A brother’s survival guilt, a journalist tracing her mutation to Lebanon, a student freezing her eggs ahead of a primary prevention trial—DIAN family members are stirring their growing community to act against Alzheimer’s disease.
Is APOB a Risk Gene for Early Onset Alzheimer’s?
Scientists link this mysterious form of dementia to higher plasma LDL-cholesterol, and to genetic variants in APOB, which encodes the major component of low-density lipoprotein.
APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation
Presented at AD/PD, the discovery by scientists in Uppsala is the first APP deletion found to cause Alzheimer’s disease. The same group found the Swedish and Arctic APP mutations.
Neurofilament in Blood Foretells Early Onset Alzheimer’s
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
Exercise Linked to Less Pathology, Better Function in Familial AD
In DIAN, participants who are more physically active may also have slower disease progression.
Gaining Notoriety, SORL1 Claims Spot Among Top Alzheimer’s Genes
Recent studies have identified rare loss-of-function variants that cause Alzheimer’s with nearly 100 percent penetrance. Now there are 17 more.
In Mice, CRISPR-Based Alzheimer’s Therapies Inch Forward
Researchers take first steps on road to targeting disease-causing APP mutations and amyloid processing.
DIAN and ADNI Data Say Familial and Sporadic AD Converge
A comparison of these large data sets shows that while the two forms of Alzheimer’s disease have separate triggers, they follow the same course and are much more similar than different.
Is Alcohol Abuse a Bigger Dementia Risk Than We Thought?
Health records from 31 million French people suggest that drinking to excess is a major risk factor for early onset dementia.
In Familial Alzheimer’s, Tau Creeps into Cortex as Symptoms Show
In people with an autosomal-dominant AD mutation, Aβ and tau start accumulating long before the estimated onset of symptoms.
Serum NfL Detects Preclinical AD, Reflects Clinical Benefit
The neurodegeneration marker appears to track disease severity in AD and MS patients with great sensitivity.
Data from DIAN Revise Familiar Biomarker Trajectories
Rather than changing one by one, many biomarkers—including cognition, tau PET, hippocampal atrophy, and CSF p-tau—shift together, around the time of symptom onset in young adults with familial AD.
CRISPR Edits Genome of Human Embryos
CRISPR-Cas9 gene editing rids embryos of a mutation causing heart disease, evoking a future where autosomal-dominant disease is prevented at the DNA level. What about AD, FTD, and ALS?
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