Presenilins, Ryanodine Receptors—Conspirators in Neurotransmission?
Presenilin mutations cause familial Alzheimer disease, but just how they do their damage is not understood...
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γ-Secretase Drives Spine Formation Via Novel Substrate
The γ-secretase has come a long way since its original discovery as the protease responsible for the production of amyloid-β peptides during sequential cleavage of the amyloid precursor protein...
DIAN Part 3: Genetic and Data Protection for Volunteers
DIAN asks a lot of its study volunteers...
DIAN Part 2: The Science, Inner Workings of the Network
Scientifically, the Dominantly Inherited Alzheimer Network (DIAN) will test three hypotheses...
DIAN: Registry for eFAD to Chart Alzheimer’s Preclinical Decade
The rarest kind of Alzheimer disease (AD)—the autosomal-dominant form that runs in families—has long been marked by its untapped opportunities...
Spain Offers Study for Families With Monogenetic Dementia, eFAD
Interest in families stricken with autosomal-dominant Alzheimer disease has intensified in the past few years...
Paper Alert: PS1 Mutations Jinx Microglia Support for Neurogenesis
Researchers report a new role for certain presenilin-1 mutations that cause early-onset familial Alzheimer disease (eFAD)...
eFAD News: Biomarkers May Help Pinpoint Disease Onset
People affected by early-onset familial forms (eFAD) often wonder how discoveries apply to them...
Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase
A third area of γ-secretase research that drew attention at the Keystone conference is the hotly debated question of how presenilin mutations cause familial Alzheimer disease...
San Diego: Microglia Enter Enrichment Stage, Human Brain Imaging of Neurogenesis
Sangram Sisodia’s group presented new data that exemplify how the expanding field of environmental enrichment and adult neurogenesis has inspired AD research...
eFAD Research Surprise: In Mutation Carriers, Amyloid Starts in Striatum
The striatum does not have a place of notoriety in Alzheimer disease research...
Movie Alert: Memories of Tomorrow Reviewed by Viewer with AD
Last Wednesday, the Japanese film <em>Memories of Tomorrow</em> premiered in Los Angeles, California...
Movie Alert: Acclaimed Film About Early-onset AD Debuts in New York
No eye-popping action scenes, no happy ending...
Beyond γ-Secretase: FAD Mutations Affect Calcium Channel via Lipid Messenger
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
Does It Fly? Age of Onset in PS-linked FAD Primarily Determined by Mutations
All presenilin mutations are not created equal. While over 130 mutations in the presenilin-1 (PS1) gene cause...
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