PAPER Dal-Pan A, Pifferi F, Marchal J, Picq JL, Aujard F, RESTRIKAL Consortium
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After DNA Damage, Phosphates Send Nuclear Protein Packing
RESEARCH NEWS 2014-06-06 Research News The nuclear protein FUS, which accumulates in the cytoplasm in some forms of frontotemporal dementia and amyotrophic lateral sclerosis (ALS), gets its marching orders from the DNA repair machinery, according to a paper in the June 4 Journal
In Surprise, Placebo, not Aβ Vaccine, Said to Slow Alzheimer’s
RESEARCH NEWS 2014-06-06 Research News On June 4, AFFiRiS AG offered a smattering of results from its Phase 2 clinical trial of AD02, an active vaccine for Alzheimer’s disease derived from the company’s proprietary method of making synthetic antigens based on the Aβ peptide. At a
PAPER Deng Q, Holler CJ, Taylor G, Hudson KF, Watkins W, Gearing M, Ito D, Murray ME, Dickson DW, Seyfried NT, Kukar T
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.
J Neurosci. 2014 Jun 4;34(23):7802-13. PubMed: 24899704Test Battery Picks Up Cognitive Decline in Normal Populations
RESEARCH NEWS 2014-06-06 Research News Researchers conducting Alzheimer’s prevention studies face a dilemma: how to measure effects on cognition in normal populations? With no validated measure available for this purpose, scientists have pioneered new instruments by combining tes
Moira Jenkins
Cork Institute of TechnologyCork, Ireland
PAPER Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M
The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.
Nat Commun. 2014 Jun 4;5:3917. PubMed: 24894631PAPER Kandalepas PC, Vassar R
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.
Curr Alzheimer Res. 2014;11(5):441-9. PubMed: 24893886PAPER Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, Tosatto L, Belluzzi E, Greggio E, Bisaglia M, Capaldi S, Aioanei D, Mammi S, Monaco HL, Samo B, Bubacco L
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity.
Hum Mol Genet. 2014 Nov 1;23(21):5615-29. Epub 2014 Jun 3 PubMed: 24895406PAPER Krismer F, Jellinger KA, Scholz SW, Seppi K, Stefanova N, Antonini A, Poewe W, Wenning GK
Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.
Parkinsonism Relat Disord. 2014 Aug;20(8):793-9. Epub 2014 May 21 PubMed: 24894118PAPER Gargiulo-Monachelli GM, Campos-Melo D, Droppelmann CA, Keller BA, Leystra-Lantz C, De Nicola AF, Gonzalez Deniselle MC, Volkening K, Strong MJ
Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord.
Eur J Neurol. 2014 Feb;21(2):273-80.e11. Epub 2013 Nov 7 PubMed: 24894997PAPER Fawaz MV, Brooks AF, Rodnick ME, Carpenter GM, Shao X, Desmond TJ, Sherman P, Quesada CA, Hockley BG, Kilbourn MR, Albin RL, Frey KA, Scott PJ
High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection.
ACS Chem Neurosci. 2014 Aug 20;5(8):718-30. Epub 2014 Jun 16 PubMed: 24896980PAPER Allgaier M, Allgaier C
An update on drug treatment options of Alzheimer's disease.
Front Biosci (Landmark Ed). 2014 Jun 1;19:1345-54. PubMed: 24896354PAPER Chen ST, Siddarth P, Ercoli LM, Merrill DA, Torres-Gil F, Small GW
Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups.
PLoS One. 2014;9(6):e98630. Epub 2014 Jun 4 PubMed: 24896243PAPER Zaręba-Kozioł M, Szwajda A, Dadlez M, Wysłouch-Cieszyńska A, Lalowski M
Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain-clues for synaptic pathology.
Mol Cell Proteomics. 2014 Sep;13(9):2288-305. Epub 2014 Jun 3 PubMed: 24895380Current Filters
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