Research Models


This database contains information about various animal models of Alzheimer’s disease and related neurodegenerative diseases, as they are important tools for biomedical research and drug discovery. This database is a work in progress and will be expanded over time. To suggest a model, updates, or corrections, please contact us at researchmodels@alzforum.org.

 

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Phenotype Summary

There is a large, ongoing effort to characterize disease models in order to better understand pathophysiology as well as to identify models suitable for investigating potential therapeutics. In support of this effort, we have collected information about core AD-related phenotypes and created interactive diagrams that facilitate comparisons. Please note, in the diagram below, as well as the others in this database, the position of the bar on the lifespan line reflects the earliest reported occurrence of the phenotype and not necessarily the age at onset.

Visualize and Compare Models

Selected Phenotypes of Commonly Used Mouse Models

When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

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