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Updated Diagnostic Criteria and Management of Lewy Body Dementia

WEBINAR 2017-10-16 Despite being arguably the second most common dementing disorder, dementia with Lewy bodies, aka DLB, remains both mysterious and understudied.  On Tuesday, October 10, 2017, the Lewy Body Dementia Association and Alzforum co-hosted a webinar discussion w

Webinar: Cortex Aging Too Fast? Blame TMEM106B and Progranulin

WEBINAR 2017-04-10 If age is the strongest risk factor for Alzheimer’s and other neurodegenerative diseases, how come some nonagenarians stay sharp while others lose their edge? Genetics beyond the known genes linked to pathologies, such as amyloid plaques and neurofibrilla

Is Alzheimer’s Disease a Uniquely Human Disorder?

WEBINAR 2016-12-07 Humans are not alone in accumulating Aβ in their brain. Squirrel monkeys, vervets, lemurs, apes, other nonhuman primates, and even dogs develop copious amyloid plaques and cerebral amyloid angiopathy as they age. However, most animals are spared the neuro

Learn About AD Biomarker Meta-Analysis on AlzBiomarker Database

WEBINAR 2016-04-08 In the April 8 Lancet Neurology, researchers led by Bob Olsson at the University of Gothenburg, Sweden, reported the most comprehensive meta-analysis of published Alzheimer’s disease fluid biomarker data to date. The researchers scoured literature going b

Webinar: Pathogenic Protein Spread? Let’s Think Again

WEBINAR 2016-03-28 Multiple lines of evidence have converged on the idea that toxic variants of Aβ, α-synuclein, and tau worm their way from one cell to the next, seeding the misfolding and aggregation of normal proteins as they go. In this manner, a growing number of scien

Fluid Business: Could “Liquid” Protein Herald Neurodegeneration?

WEBINAR 2015-10-08 Could the protein aggregates that cause neurodegeneration turn out to be the cellular equivalent of ice cubes? Scientists investigating how proteins naturally transition between gas-like solutions, condensed liquids, solidified gels, and insoluble fibrils

Computational Modeling—Will it Rescue AD Clinical Trials?

WEBINAR 2015-05-01 The Alzheimer's field has had its share of clinical trial flops. Now there's a push to learn from past failures. Computational scientists in pharmaceutical companies are guiding clinical trial design by first putting drug candidates through thei

Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?

WEBINAR 2015-01-30 To sate the brain’s voracious hunger for energy, thousands of capillaries deliver blood and oxygen to every sulcus and gyrus, and the white and gray matter in between. Herein lies a problem. The delicate cells of the brain must be protected from the flots

Good-Bye Overexpression, Hello APP Knock-in. A Better Model?

WEBINAR 2014-04-13 Researchers rely on transgenic mice to model Alzheimer's disease, but these models are far from perfect. Some can only be maintained on specific genetic backgrounds, some die young or have surprising phenotypes when crossed with other mouse lines, an

Neurovascular Underpinnings of Alzheimer's Dementia

WEBINAR 2013-12-06 Whether it’s a Bach concerto, Fermat's last theorem, or simply remembering the way home from the grocery store, cognition comes at a price. The brain depends on an elaborate network of blood vessels to feed its voracious appetite for oxygen and gluco

Webinar: O Blood-Based Biomarker, Where Art Thou?

WEBINAR 2013-06-17 Our Webinar on 17 June 2013 covered the latest research and future directions on blood-based biomarkers discussed at a recent Alzheimer’s Drug Discovery Foundation/Alzheimer’s Association conference. Sid O’Bryant, Texas Tech University, Lubbock; Samantha

Can Network Analysis Identify Pathological Pathways in Alzheimer’s

WEBINAR 2013-06-04 See Q&A with panelists below In the April 25 Cell, Valur Emilsson at the Icelandic Heart Association and Eric Schadt at Icahn School of Medicine at Mount Sinai, New York, report that they have identified molecular networks that are perturbed in Alzhei

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