Roslyn Stanford
Calwell, Australia
329938 RESULTS
Calwell, Australia
RESEARCH NEWS 2014-04-25 Research News In Alzheimer’s brains, the axonal protein tau strays into dendritic spines and stirs up trouble at synapses. Researchers have called this a mislocalization, but a paper in the April 23 Journal of Neuroscience challenges this view, suggesting
COMMENT This study from the Buisson lab adds more data arguing that tau may contribute to the regulation of synaptic plasticity. It has long been known that tau can bind to f-actin, particularly when phosphorylated at the KXGS-motifs (Mandelkow et al., 2004; Whit
RESEARCH NEWS 2014-04-25 Research News Long repeat sequences in the C9ORF72 gene have cropped up in cases of multiple system atrophy (MSA) and depressive pseudodementia, according to two new case studies. The findings, published in JAMA Neurology on April 14 and 21, respectively,
Germany
PAPER MacArthur DG, Manolio TA, Dimmock DP, Rehm HL, Shendure J, Abecasis GR, Adams DR, Altman RB, Antonarakis SE, Ashley EA, Barrett JC, Biesecker LG, Conrad DF, Cooper GM, Cox NJ, Daly MJ, Gerstein MB, Goldstein DB, Hirschhorn JN, Leal SM, Pennacchio LA, Stamatoyannopoulos JA, Sunyaev SR, Valle D, Voight BF, Winckler W, Gunter C
COMMENT I enjoyed reading this paper. The study adds to the notion that a prime function of tau is that of a scaffolding protein, not only in the axon but also in the dendrite where tau interacts, as this study shows, also with filamentous actin. Interesting is t
University of California San FranciscoSan Francisco, United States
COMMENT This is a very interesting and elegant study that adds support for the idea that tau is normally present in dendrites and plays a physiological role in normal synaptic functioning. The movement of tau into spines with neuronal activity is demonstrated in
PAPER Frandemiche ML, De Seranno S, Rush T, Borel E, Elie A, Arnal I, Lanté F, Buisson A
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PAPER Mohammadi D
PAPER Sharma M, Krüger R, Gasser T
PAPER Zahodne LB, Schofield PW, Farrell MT, Stern Y, Manly JJ
PAPER Welberg L
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