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Return of the Small Family Study? Whole-Genome Analysis Shows Power
12 March 2010. In an era of genetics research where huge cohorts seem to be the name of the game, two new papers highlight the power of small...
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MicroRNAs—Oligarchs of Oligodendrocyte Fate
12 March 2010. Don’t let the name fool you; there’s nothing minor about microRNAs...
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BDNF—Learning Boosts Trophin Signals in Hippocampus
11 March 2010. Exactly how does using one’s brain defend against the dreaded loss of faculties?...
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Synuclein Modifications: Caveat Emptor With Those Phosphomimetics
11 March 2010. When good proteins go bad in neurodegenerative diseases, the road to ruin often runs through modification and via aggregation to toxicity...
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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Alzheimer’s Prevention Initiative: Trials in People at Highest Risk
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The field is abuzz with the word “prevention,” but how to pull off this vaunted goal? It's been held back by a strange Catch-22 of cost, time, and biomarker validation. That might change with a bold initiative led by Eric Reiman, Pierre Tariot, and others at the Banner Alzheimer's Institute. For the past two years, they have been laying the groundwork for what they hope will be an era of collaborative prevention research of shared risks and shared rewards. Their plan? They propose starting this era by offering two presymptomatic treatment trials next year to people who are cognitively normal yet face an extremely high risk of developing AD symptoms in the next few years. These people are middle-aged carriers of a deterministic AD mutation from a large set of families in Colombia, and elderly people in the U.S. and perhaps abroad who carry two copies of the ApoE4 risk gene. Start treatment trials in them, the thinking goes, and similar trials for many more at-risk people might follow. Read Gabrielle Strobel's five-part series. See also a PDF of the entire series.
 Vision of Shared Prevention Trials Lures Pharma to Table
Can Alzheimer’s Prevention Initiative Break a Catch-22?
Trials in Colombia and the U.S. for Those at Highest Risk?
For Shared Prevention Trials, Devil Is in the Details
Making Trials Work for Patient, Sponsor, Regulator
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Don't Forget! NACC Data Are Freely Available
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Walter Kukull reminded us that longitudinal data collected from all of the NIA-funded Alzheimer's Disease Centers are available to all researchers—free!—from the National Alzheimer's Coordinating Center (NACC). "I know there has been confusion in the past about whether these data were available to non-ADC researchers," writes Dr. Kukull. "The data are indeed available. Check it out on the website. There is a brief form to complete if a data file is requested; this is a similar procedure to what ADNI has required of researchers. Brief aggregate data queries can be done online. The NACC database includes data from nearly 20,000 subjects (demented+MCI+normal)." |
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ALZFORUM IS ON TWITTER
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You can now follow Alzforum on Twitter. Go to AlzforumTweet and click on "Follow." If you don't have a Twitter account, you will be prompted to sign up. We will be doing all kinds of cool things, so sign up now!! To monitor AlzforumTweet, just keep your Twitter homepage open on your Web browser. It will not clutter up your e-mail or text inboxes unless you elect to have tweets sent to your e-mail or phone. Interested in having Alzforum conduct a Webinar to learn how to use Twitter? Contact us to let us know.
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What's New
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Conferences - Posted 12 March 2010
Evolution of Brain Aging and Cognitive Decline: Lecture by Bruce Yankner: 25 March 2010, Harvard Medical School, Boston, MA, U.S.A. |
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Comments - Posted 12 March 2010
Read remarks by Ruth Itzhaki, Curtis Dobson, Matthew Wozniak about Soscia SJ et al.
PAPER: The Alzheimer's Disease-Associated Amyloid beta-Protein Is an Antimicrobial Peptide. |
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Comments - Posted 12 March 2010
Read remarks by Peter Nelson about
Zhao X et al.
NEWS: MicroRNAs—Oligarchs of Oligodendrocyte Fate |
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Comments - Posted 12 March 2010
Read remarks by Zhigang He about
Zhao X et al.
NEWS: MicroRNAs—Oligarchs of Oligodendrocyte Fate |
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Comments - Posted 12 March 2010
Read remarks by Sebastien S. Hebert about
Zhao X et al.
NEWS: MicroRNAs—Oligarchs of Oligodendrocyte Fate |
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Comments - Posted 12 March 2010
Read remarks by Linda Avey about Roach JC et al.
PAPER: Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing. |
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Comments - Posted 12 March 2010
Read remarks by George Church about Roach JC et al.
PAPER: Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing. |
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Comments - Posted 11 March 2010
Read remarks by Masakazu Hashimoto, Lars Tjernberg about Hashimoto M et al.
PAPER: Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology. |
SEE MORE |
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Registered Alzforum members will receive a 10 percent discount to attend the 2nd Annual Drug Development for Neurodegenerative Diseases Conference in Boston, 18-19 May 2010. E-mail your interest in registering at the discounted "Alzforum rate."
View conference details.
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 Check out our most recent Webinar/Live Discussion: Together at Last, Top Five Biomarkers Model Stages of AD, held 21 January 2010.
Check out our Webinar/Live Discussion: Of Mice and Men: Bridging the Translational Disconnect in CNS Drug Discovery, held 17 December 2009.
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The AlzRisk Epidemiology Database provides a publicly available collection of published studies on the impact of putative environmental risk factors and protective factors related to Alzheimer disease in longitudinal cohort studies.
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AlzGene
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MSGene
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PDGene
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SZGene
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An up-to-date collection of all published genetic association studies. |
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Announcing Alzheimer's Research & Therapy, a new online peer-reviewed journal which publishes open access research articles of outstanding quality in Alzheimer's research.
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Download Powerpoint Presentations created by top experts in neurodegenerative disease research. Available for educational or personal use. Edited by Daniel M. Michaelson, PhD, and Tobias Hartmann, PhD.
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The Drug Development Company Database and Tutorial represent the collaborative efforts of the Alzheimer's Drug Discovery Foundation (ADDF)/Institute for the Study on Aging (ISOA) and the Alzheimer Research Forum. Our thanks to ADDF, Jens Eckstein, and the Advisory Board for bringing this project to fruition.
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Home
