Genetics

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ALZGENE

AlzGene is a collection of published Alzheimer's disease genetic association studies, with random-effects meta-analyses for polymorphisms with genotype data in at least three case-control samples.

HEX

The Healthy EXomes database is a repository of benign genetic variability. It contains whole-exome sequencing data from individuals over the age of 65 who were confirmed postmortem to be neuropathologically normal. Coming soon!

MUTATIONS

The mutations database provides a list of rare variants reported in the three genes known to cause autosomal-dominant familial Alzheimer’s disease — APP, presenilin-1 and presenilin-2 — as well as those reported in MAPT (tau). Classsifying variants as "pathogenic" or "not pathogenic" is an ongoing challenge in the field and these classifications must be interpreted with caution as they are subject to change as new data become available.