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CONFERENCE COVERAGE 2000-12-20 Conference Coverage Presenilin-1 and-2 (PS1, PS2) gene mutations appear to cause the majority of cases of early onset familial Alzheimer’s disease (EO-FAD). In this presentation Potter et al. (492.2) presented data that PS1 and PS2 (the PS's) have a
CONFERENCE COVERAGE 2000-12-20 Conference Coverage Presenilin-1 and-2 (PS1 and PS2) are members of a (growing) family of genes which encode polytopic integral transmembrane proteins homologous to the Notch cell surface receptors of Drosophila and the sel-12 element of the C. elegans ge
RESEARCH NEWS 2000-12-19 Research News Two immune proteins found in the brains of mice help the brain develop and may play key roles in triggering developmental disorders like dyslexia and neurodegenerative disorders like Parkinson's disease, according to a Harvard Medical S
RESEARCH NEWS 2000-12-15 Research News Mutations in the genes for α-synuclein and parkin have been linked to early onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear. Now an analysis of families in Iceland indicates that the
WEBINAR 2000-12-12 Chris Weihl led this live discussion on 12 December 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held on 12 December 2000 and moderated by Chris Weihl. Participan
RESEARCH NEWS 2000-12-07 Research News Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage, California, and his coworkers at the Salk Institute in the current issue of the Journal of Neuroscience. Bec
CONFERENCE COVERAGE 2000-12-01 Conference Coverage Reported by Benjamin Wolozin, Natalie Golts and Peter Choi, Loyola University Medical Center The meeting in New Orleans demonstrated that the biology of α-synuclein and parkin are progressing at a rapid pace. Aggregation of α-synuclein
RESEARCH NEWS 2000-11-30 Research News Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could, therefore, be an important targ
COMMENT [I would like to note] that back in [August] 2000, we published a paper in Neurobiology of Disease (Refolo et al., 2000) demonstrating for the first time that cholesterol metabolism accelerates β-amyloid accumulation in a transgenic mouse model of AD. We
RESEARCH NEWS 2000-11-29 Research News Statins have recently appeared on the radar screen for Alzheimer's researchers because of studies by Ben Wolozin and his colleagues showing that people who take the cholesterol-lowering drugs have a significantly reduced risk of Alzheim
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RESEARCH NEWS 2000-11-22 Research News The abnormal prion protein, but not the normal prion protein, binds with high affinity to plasminogen, a plasma component that has been linked to neurotoxicity, according to a report in the current Nature. Besides the obvious fact that this
COMMENT Yes, at least some consensus would be appreciated, especially for people new to this field. For example, at the recent Neuroscience meeting in New Orleans, people were hedging on the latter case (presenilin-1 or γ-secretase?) even to the extent of questio
COMMENT There is nothing that upsets me faster than scientists using inappropriate and imprecise terminology and nomenclature. With respect to the Alzheimer's disease lexicon, the WHO and the International Nomenclature Committee on Amyloidosis have ALREADY d
CONFERENCE COVERAGE 2000-11-17 Conference Coverage Last year, Brad Hyman’s group reported on their ability to image amyloid plaques in the brains of live PDAPP Tg mice. Plaques could be detected as deep as 200 microns and the same plaques could be imaged over the course of weeks using
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