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CONFERENCE COVERAGE 2000-11-09 Conference Coverage The award for most aesthetically pleasing presentation almost certainly could go to Dr. Paul Thompson, who reviewed recent advances being made by a UCLA team in developing AD-specific brain atlases for assessing alterations in the brai
CONFERENCE COVERAGE 2000-11-09 Conference Coverage At least I hope they will come. Brian Cummings presented an overview of a web-based database for Alzheimer’s cases (known as the Neuropathological Examination Research Database or NERD) that could serve as a model for other AD centers
RESEARCH NEWS 2000-11-07 Research News A number of lines of evidence implicate oxidative damage caused by free radicals-particularly reactive oxygen species-as having some role, perhaps even a major or causative one, in the etiology of neurodegenerative diseases. Writing in Scien
CONFERENCE COVERAGE 2000-11-06 Conference Coverage Douglas Kerr and colleagues at Johns Hopkins (Abstract 209.13) reported success in using neural stem cells to restore function in an animal model of spinal motor atrophy (SMA). In SMA, the ventral horn motor neurons that innervate musc
RESEARCH NEWS 2000-11-05 Research News Parkinson's disease is one of the most common neurodegenerative diseases, affecting about one percent of all people over the age of 65. It is characterized by rigidity, bradykinesia (reduced movement) and tremors, which are caused by th
CONFERENCE COVERAGE 2000-11-05 Conference Coverage A central problem in Alzheimer's disease is to understand how Aβ affects the brain's biology, and how it contributes to neurodegeneration. A diverse array of mechanisms have been proposed, including direct toxicity, generatio
RESEARCH NEWS 2000-11-01 Research News It is not only the abnormal product of amyloid precursor protein-the amyloid-beta peptide-that interests researchers of Alzheimer's disease. There is also a line of inquiry that hopes to find clues to the disease in the normal function
CONFERENCE COVERAGE SERIES William Harvey Research Conference: The Role of COX-2 Inhibitors in Inflammatory and Other Diseases William Harvey Research Conference
RESEARCH NEWS 2000-10-27 Research News Following on the heels of a report on a two-gene therapy approach to rescue neurons in a mouse Parkinson's model, a new study published today in Science finds that GDNF genes delivered by a lentiviral vector reversed functional deficits
CONFERENCE COVERAGE 2000-10-27 Conference Coverage The 15 invited conference speakers reported their most current findings on cyxlooxygenase (COX-1 and COX-2) inhibitor research including the latest technical developments concerning the relevance of COX-2 (inducible cyclooxygenase-2) s
CONFERENCE COVERAGE SERIES Gene Therapy Rescues Neurons in Parkinson's Model American Neurological Association: 2000 Annual Meeting
RESEARCH NEWS 2000-10-05 Research News Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain and matu
CONFERENCE COVERAGE 2000-10-05 Conference Coverage A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany. The study was carried out in an MPTP mouse mo
RESEARCH NEWS 2000-10-04 Research News Researchers announced a step forward in the rational design of drugs to inhibit β-secretase (also called memapsin 2 and BACE) with the publication in tomorrow's Science of the crystal structure of the enzyme locked in a complex with a n
RESEARCH NEWS 2000-10-02 Research News A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues in this month
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