345683 RESULTS
CONFERENCE COVERAGE 2000-07-13 Conference Coverage The centrality of the amyloid hypothesis for AD pathology is evident at this conference not only by the sheer number of papers and posters devoted to it (708 out of a total of 1279, as opposed to 163 for apoE and 152 for presenilin, fo
CONFERENCE COVERAGE 2000-07-13 Conference Coverage The potential contribution of ApoE to AD pathology was cast in a novel light in data presented as a poster today by Huang et al. They were studying the fate of ApoE when expressed by transient transfection in Neuro-2a cells. The ApoE w
CONFERENCE COVERAGE 2000-07-13 Conference Coverage Reported by Walter Lukiw. www.elsevier.com/locate/niad2000 Classical and Alternative Pathways-Neil Cooper. It has been a century since Alzheimer and Bielchowsky reported senile plaques (SP) in AD brain, but it was only relatively rece
RESEARCH NEWS 2000-07-12 Research News Do individual neurons gradually waste away in inherited neurodegenerative diseases, or are they functioning more or less normally until one catastrophic event does them in? A study published in tomorrow's Nature suggests that a "on
CONFERENCE COVERAGE 2000-07-11 Conference Coverage One of the first symposia of the conference was dedicated to an overview of the current and future treatments for AD. Six presenters gave their perspectives on many treatment issues ranging from management of behavioral disturbances to
CONFERENCE COVERAGE 2000-07-11 Conference Coverage Amyloid plaques are still the main attraction, and tangles have certainly not left the stage, but there is still a lot of interest at this meeting (off-Broadway, so to speak) in other potential players in AD pathology. An example is Ap
CONFERENCE COVERAGE 2000-07-10 Conference Coverage The editors of the Journal of Alzheimer Disease announced today that Suzanne de la Monte was the recipient of its Alzheimer Medal for best article published in the past year. De la Monte was lauded for her article, "Cerebrovascula
RESEARCH NEWS 2000-07-03 Research News Transplanted stem cells have provided compelling news stories in recent years, promising regeneration of damaged nervous systems, but another possibility-that the adult brain itself could provide the pluripotent cells to replace damaged neur
RESEARCH NEWS 2000-07-03 Research News One of the challenges to diagnosing Alzheimer's disease is the lack of a nonbehavioral clinical test. The definitive diagnosis can only be made when amyloid plaques and neurofibrillary tangles are seen at autopsy. Virginia Lee, Daniel S
RESEARCH NEWS 2000-07-03 Research News Finding a safe way to get therapeutic genes past the blood-brain barrier has led to some interesting approaches using the barrier's own transport systems to shuttle DNA across the blood capillary wall from the bloodstream into the brain
RESEARCH NEWS 2000-07-03 Research News Results presented by three research groups this week all confirm that presenilin is, at the least, essential for γ-secretase to cleave amyloid precursor protein in the process that release amyloid-β. In fact, say these authors, the results l
RESEARCH NEWS 2000-06-30 Research News The discovery that Huntington's disease results from a particular mutation of the gene for the protein dubbed "huntingtin" has created great hope that this neurodegenerative movement disorder will soon have effective treatment
RESEARCH NEWS 2000-06-26 Research News How are short-term memories converted to long-term memories? The process is certain to be complex, and a study in the 23 June issue of Science suggests thetranscription factor NPAS2 may play an important role, perhaps by regulating circadian
CONFERENCE COVERAGE 2000-06-17 Conference Coverage Peter Lansbury, like I and others, has long promulgated the idea that intermediates in CNS disease-related fibrillogenesis processes are likely to be pathogenic, whereas mature matted fibrils (although not desirable) are relatively ine
CONFERENCE COVERAGE 2000-06-17 Conference Coverage Last July, Dale Schenk and colleagues from Elan Pharmaceuticals reported the remarkable observation that simple immunization of PDAPP transgenic mice with amyloid-forming peptide sequences both prevents plaque formation and ameliorates
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