345638 RESULTS
RESEARCH NEWS 2000-06-14 Research News Creatine, increasingly popular as a dietary and exercise supplement, has shown the ability to counteract laboratory models of amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), Huntington's disease, and Parkinson's
RESEARCH NEWS 2000-06-08 Research News The true identity of γ-secretase, the enzyme that frees amyloid-β from its membrane-bound precursor, is one of the holy grails in the search for the cause of Alzheimer's disease. A battery of circumstantial evidence has recently focused
RESEARCH NEWS 2000-05-19 Research News The cysteine protease calpain cleaves the cdk5 regulator p35, releasing a 25KD fragment that accumulates in the brains of people with Alzheimer’s disease. What’s more, Aβ42 is among the factors that trigger this reaction, report Li-Huei Tsai
RESEARCH NEWS 2000-05-19 Research News According to a report in today's Science, a productive approach to combating the spongiform encephalopathies such as the transmissible "variant" Creutzfeldt-Jacob disease (vCJD, popularly known as "mad cow disease")
COMMENT Reply to Sam Gandy by Gunnar Gouras We all agree that "full-blown" structural pathology (plaques and tangles) precede and accompany dementia. What we are especially considering is whether there is any role for intraneuronal Aβ in causing neurona
WEBINAR 2000-05-16 Gunnar Gouras led this live discussion on 16 May 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 16 May 2000. Participants: Bruce Yankner, Huaxi Xu, Austin Ya
COMMENT From various studies examining the toxicity of Aβ, it is clear that random coil monomeric Aβ is not toxic whereas oligomeric aggregates (protofibrils, ADDLs or fibrils) are. Thus the critical issue with respect to Aβ toxicity is its aggregation state. An
COMMENT The idea that intracellular Aβ injures neurons and causes dementia prior to the formation of extracellular deposits is not obviously reconcilable with other evidence indicating that "full-blown" structural pathology precedes dementia (Crystal H,
RESEARCH NEWS 2000-05-08 Research News The DNA sequence of human chromosome 21 will be published electronically today in Nature (and in print on 18 May). This achievement, by an international consortium of 62 scientists in Japan, Germany, France, Switzerland, the USA and Britain,
RESEARCH NEWS 2000-05-05 Research News The neuronal peptide α-synuclein is an important constituent of the Lewy bodies, pathological hallmarks of the Lewy body variant of Alzheimer's disease, as well as of Parkinson's and several other neurodegenerative diseases. Beyond
INTERVIEWS 2000-04-26 Interviews ARF: What is the primary hypothesis that guides the research in your lab? BW: My laboratory's research is focuses on two different projects: presenilins (PS) and alpha-synuclein. With regard to presenilins the primary hypothesis that we ar
RESEARCH NEWS 2000-04-24 Research News Many researchers believe that the amyloid-β peptide is a culprit in the neurodegenerative process of Alzheimer's disease. Indeed, they can marshal good evidence that the fibrillar form of Aβ kills neurons in a petri dish. If this is ind
RESEARCH NEWS 2000-04-24 Research News Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that the 31 amino-acid pe
RESEARCH NEWS 2000-04-13 Research News Inhibiting cell death proteases, or caspases, can prolong the life of mice with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), Robert Friedlander of Harvard Medical School and Brigham and Women’s Hospital, Boston, Massac
COMMENT This letter is in response to the recent article in Journal of Clinical Microbiology (38[2]:881-882, 2000) entitled "Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's Disease Patients" by Gieffers et al. Since we were
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