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A Kinder, Gentler Alzheimer's Vaccine?

RESEARCH NEWS 2001-08-17 Research News Thomas Wisniewski, Einar Sigurdsson, and colleagues at New York University report that they have prevented amyloid-β deposition by immunizing a mouse model of Alzheimer's disease with a nontoxic Aβ homologue. These results, they suggest

Pluripotent Stem Cells from Adult Mammalian CNS...

RESEARCH NEWS 2001-08-16 Research News In the August 16 Nature, scientists in the laboratory of Perry Bartlett, at the Walter and Eliza Hall Institute of Medical Research, Victoria, Australia, report the successful isolation of multipotent stem cells from adult mice. The research

Ming Chen on Nomenclature Discussion

COMMENT Clarification of the confusing terms such as Aβ, βA, APP, βAPP or AβPP will help the field if they can be standardized. But here, I would like to reiterate the key importance of another "nomenclature" problem, i.e., "Alzheimer's diseas

Antibody Clears Prion Infection

RESEARCH NEWS 2001-08-15 Research News While therapeutic Aβ antibodies are wending their way through clinical trials, researchers studying other offending brain proteins have been racing to work out similar strategies. In the August 16 Nature, Anthony Williamson and Dennis Burton

Nomenclature Discussion

WEBINAR 2001-08-15 George Perry and Mark A. Smith led this live discussion on 14 August 2001. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 14 August 2001, 5 p.m. EST Participants: Co

Neurofilaments May Be Essential to Some Tauopathies

RESEARCH NEWS 2001-08-14 Research News It appears that some tauopathies require the presence of neurofilaments for neurodegeneration to occur. In the 15 August Journal of Neuroscience, Virginia Lee, Takeshi Ishihara, and colleagues at the University of Pennsylvania describe how t

Putting Parkinson's Placebo Effect on a Chemical Footing

RESEARCH NEWS 2001-08-09 Research News A study published in May in the New England Journal of Medicine questioned long-held views on the placebo effect, sparking intense debate (Hrobjartsson and Gotzsche). In the August 10 Science, scientists in Jon Stoessl's laboratory at t

Erythropoietin a Neuroprotectant?

RESEARCH NEWS 2001-08-08 Research News Pretreatment with the hormone erythropoietin (EPO) can protect neurons in models of neurodegenerative and stroke-related cell death, according to a paper in today's Nature. The authors, Stuart Lipton of the Burnham Institute in La Jolla

Enabling Technologies 2001 Workshop Summary

CONFERENCE COVERAGE 2001-08-06 Conference Coverage In August 2001, a diverse group of academic and industry investigators from within and outside of Alzheimer's disease research participated in this workshop in Bar Harbor, Maine. The goal was to identify critical knowledge gaps th

Summary of Scientific Discussions: Bar Harbor

CONFERENCE COVERAGE 2001-08-06 Conference Coverage Robert Balaban opened the discussion by observing that heart disease and AD research share certain characteristics, including a weak familial linkage, poor penetrance of some of the known risk factors, and a poor understanding of the i

Summary of Technology Discussions: Bar Harbor

CONFERENCE COVERAGE 2001-08-06 Conference Coverage Tim Clark began by laying out recommendations about the information infrastructure required if many groups want to be able to do collective experimentation, to share data, and to exploit automated pattern recognition in that shared dat

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