345052 RESULTS
RESEARCH NEWS 2001-10-25 Research News Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA-mRNA, tRNA, rRNA-has just gotten a baby brother. Three independent research teams are reporting in tomorrow's Sci
RESEARCH NEWS 2001-10-19 Research News One hypothesis for how polyglutamine (poly-Q) repeats in the huntingtin protein might cause disease holds that they somehow perturb gene expression. This notion is getting more traction from a paper in yesterday's Nature, which shows no
RESEARCH NEWS 2001-10-19 Research News Another theory to explain Huntington's suggests that proteolysis of polyglutamine-expanded (poly-Q) huntingtin by caspase enzymes generates toxic N-terminal peptide fragments. Though caspases are required for apoptosis induction by muta
COMMENT Comment by Mark Gluck, Kin Ho Chan, M. Todd Allen Although these results are intriguing, the authors' interpretation of them seems to go beyond what the data actually might support. Briefly, the pattern of results they report is that as you look at a
RESEARCH NEWS 2001-10-18 Research News The Where? Key Role Found for Entorhinal Cortex, Area of Earliest Neuron Death in Alzheimer's It has become almost a truism in memory research that the seahorse-shaped brain area called the hippocampus is key to memory formation. It hel
RESEARCH NEWS 2001-10-15 Research News Chronically elevated levels of cyclooxygenase-2 (COX-2), which catalyzes the first step in the synthesis of prostaglandins from arachidonic acid, have been correlated with induction of neuronal apoptosis, suggesting this enzyme may play a ro
RESEARCH NEWS 2001-10-15 Research News Mitochondria, through their pivotal roles in apoptosis and generation of reactive oxygen species (ROS), are increasingly being implicated in the pathogenesis of neurodegenerative diseases. Researchers in the lab of Nils-Göran Larsson at the
RESEARCH NEWS 2001-10-15 Research News Last year researchers identified a mutation in rats, the so-called agu mutation (Payne et al), which resulted in a phenotype resembling human Parkinsonism. In November's Nature Neuroscience, available online today, scientists at Wayne D
RESEARCH NEWS 2001-10-10 Research News 10 October. In tomorrow's Science, researchers describe how developing a new method dubbed "pharmacological knock-in" has enabled them to fill in the missing pieces of an unusual signal transduction pathway that links changes
RESEARCH NEWS 2001-10-09 Research News Researchers have suspected retroviruses to play a role in amyotrophic lateral sclerosis (ALS) since the 1960s, when poliomyelitis was proposed to contribute to progression of the disease. Through the '80s and '90s, ALS syndromes as
COMMENT α-Synuclein and β-amyloid: A Linking of Partners to Model Disease Creating transgenic models of neurodegenerative disease has yielded mixed results. The transgenic models of Huntington's chorea and amyotrophic lateral sclerosis have yielded animal mo
RESEARCH NEWS 2001-10-08 Research News A new double-transgenic mouse may provide a good model for Lewy-body diseases and offer insight into mechanisms that underlie Alzheimer's and Parkinson's disease. Eliezer Masliah and colleagues at University of California, San Dieg
RESEARCH NEWS 2001-10-06 Research News Spinocerebellar ataxia type 7 (SCA7), which causes retinal cone-rod degeneration and eventual blindness, can be traced to the expansion of a CAG trinucloetide repeat-from 10 to as many as 250 triplets-in the SCA7 gene. These mutations result
RESEARCH NEWS 2001-10-05 Research News Two very different reports suggest that testosterone may be important in protecting neurons from Aβ, the peptide suspected of killing neurons in Alzheimer's disease. The first, from Andrea LeBlanc, Morrie Gelfand, and colleagues at McGi
RESEARCH NEWS 2001-10-03 Research News Tomorrow's Nature magazine carries an article on head trauma that could inform parts of Alzheimer's research, as well. Esther Shohami at Hebrew University's Medical Faculty in Jerusalem, and colleagues there, report that an en
No filters selected
