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COMMENT Another piece of evidence that elevated phospho-tau levels, in the absence of tau aggregation, causes toxicity. This fits with our publications referenced below. 0 j.goetz Parkinsonism and impaired axonal transport in a mouse model of frontotemporal demen
COMMENT This is an interesting paper shedding light on the enigma of 'selective vulnerability' in AD. 0 j.goetz
COMMENT This is interesting, also in the context of the Steinhilb/Feany publication (which is discussed in the article) on concerted action of tau phosphorylation sites rather than specific sites playing a role. 0 j.goetz
COMMENT The authors state that “perturbation of the transport of a limited set of proteins has been occasionally reported for other neurodegenerative diseases [than Alzheimer's].” In fact, we have shown that the anterograde transport of distinct cargos is im
COMMENT In establishing a link between the Aβ and tau pathologies, Zhang and colleagues used an elegant screening approach called random homozygous gene perturbation (RHGP). It allowed them, in mouse N2a cells, to identify a retrotransposed gene that “interacted”
COMMENT This is an excellent review; in particular, Table 1 listing therapeutic treatments for targeting neuronal mitochondria is very helpful. 0 j.goetz
COMMENT This is a very interesting hypothesis, with a beautiful figure to accompany it. 0 j.goetz
COMMENT This is a very carefully performed behavioral and electrophysiological study of an established tau mouse model. AD is a synapse failure. 0 j.goetz
COMMENT This is a nice model with a tauopathy in the absence, apparently, of tau filament formation. This complements the previously generated BAC human tau transgenic mice by Peter Davies and colleagues. Following their line of investigation, it would be interes
COMMENT The title of this remarkable paper in Nature Cell Biology highlights two key findings: that a tau pathology can be transmitted in vivo, and that it spreads through the brain. The former is a feature of transmissible prions (a characteristic as enigmatic a
COMMENT This is an excellent paper demonstrating that the spreading of tau pathology in the hippocampus reflects neuroanatomical connectivity. Figure 4 is excellent for presentations that address selective vulnerability, staging and progression in AD. 0 j.goetz
COMMENT I recommend this paper. A nice follow-up would be to use ICP (laser ablation-inductively couple plasma-mass spectrometry, LA-ICP-MS). 0 j.goetz
COMMENT An interesting method of delivering proteins (such as alpha-synuclein) to neuronal cells using nanoparticles. 0 j.goetz
COMMENT An excellent study supporting the mitosis failure hypothesis. We have shown previously using Affymetrix gene chips that Aβ treatment and P301L tau expression in an Alzheimer disease tissue culture model act synergistically to promote aberrant cell cycle r
COMMENT Like all of Michel Goedert's articles, this is another example of a very carefully researched, insightful (and personal) article on Oskar Fischer, whose work and life is worth remembering. For me as a German, am grateful to be reminded of what the Na
