11505 RESULTS
COMMENT I was extremely saddened by the news that Francisco had passed away. I recall us saying goodbye to each other at the AAIC meeting in Philadelphia only a few weeks ago. He was such a magnificent inspiration to anyone working in the field of Alzheimer’s dis
COMMENT This study provides important evidence supporting a biphasic neurophysiological model of Alzheimer’s disease (AD) progression, as previously proposed by Harris et al., 2020. Several studies from multiple laboratories have established a clear sequence in m
COMMENT After decades of the X chromosome remaining in the dark, it is wonderful now to have, in addition to ours, two additional Alzheimer’s disease XWAS papers see the light of day (Le Borgne et al., 2024; Simmonds et al., 2024). I believe this corroborates the
COMMENT In this paper, Green et al. use single-cell analyses of 1.6 million cells and the BEYOND framework, along with mediation modeling, to explore the cellular dynamics of AD. They attempt to distinguish the progression to AD (referred to as "prAD")
COMMENT This is one of four contemporary large-scale efforts to apply single-cell profiling to the neocortex in a cohort of AD donors. The other three are our own (coming out in November in Nature Neuroscience), Li-Huei Tsai’s in Cell last year, and Evan Macosko’
COMMENT This paper is a significant achievement. Along with recent datasets from the Allen Brain Institute and MIT, it represents the latest generation of Alzheimer's nuc-Seq atlases notable for the large number of samples and cells analyzed. The insights em
COMMENT This fascinating and timely study really deepens our understanding of cellular dynamics in aging and Alzheimer’s disease. The use of single-cell RNA-Seq on such a large cohort of brains is impressive and allows for an unprecedented look at the specific mi
COMMENT Belloy et al. performed an XWAS for AD by analyzing 15,081 clinical-AD cases, 41,091 registry-AD and Alzheimer’s disease and dementia (ADD) cases and 82,386 proxy-ADD cases. They identified a genome-wide significant (P<5x10-8) signal in the SLC9A7 locu
COMMENT In their timely and well-executed study, Belloy et al. conducted a large-scale X-chromosome-wide association study of the genetics of Alzheimer’s disease. Their approach is novel and much-anticipated because the X chromosome has been largely excluded in g
COMMENT I met Francisco, whom we affectionately call Pacho, in the 1980s when he did a residency in neuropsychology at the Neurological Institute of Colombia in Bogotá under the mentorship of Alfredo Ardila, my deceased husband. In the 1990s and in the years 2000
COMMENT Rudolf Virchow, the founder of cellular pathology, would have been thrilled, and perhaps even awestruck, to have witnessed this sweeping investigation of the formation and molecular characteristics of α-synuclein cellular inclusions. The novel cell lines
COMMENT These two articles by the groups of William A. McEwan and Leo C. James are very interesting and show two different but related therapeutic approaches to clear pathological tau. Both rely on the RING-domain of TRIM21, with one using a single-domain antibod
COMMENT I think these are very promising and exciting strategies, especially the nanobody-based approach. This provides true specificity of binding/degradation. The protein fragment-based strategy could work, but could also conceivably have off-target binding, or
COMMENT uncomfortable. He was excited about my comments on postmortem studies of Einstein’s brain and asked me for more
COMMENT Colleagues and friends including Joe, Diego, and Ken, who knew Francisco better than I did, have already given wonderful accounts of his life and times. I echo those sentiments and reminisces, and indeed it was an honor and privilege to know Francisco Lop
