11572 RESULTS
COMMENT Reply to Ratan Bhat by Rudy Tanzi: The main problem with this hypothesis is that since the time of publication of the commentary by Tuck Finch and I in Science, we now know that PS2 does not bind β- or delta-catenin (Tesco et al., J. Biol Chem., 1998). Ye
COMMENT some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1,
COMMENT Nature, I thought it would be helpful to indicate several points about your comments regarding the role of
COMMENT As a quick comment regarding Luc Buee's summary of Dr. Lindsay Farrer's talk on the
COMMENT Dr. Lukiw does not mention that Dr. Peggy Vance reported that she replicated our significant genetic association of A2M and AD using the same A2M polymorphism (exon 18 deletion) in the same AD families (NIMH AD family set N = ~350) that we used and with t
COMMENT Dear Dr. Kosik, It was an honor that our work, presented at the Sixth International Conference on AD, was described in your briefing about presenilin-binding proteins. Similarly to your team and the identification of the catenins as possible modulators of
COMMENT This necessary study supports, once again, the idea that microglia do not affect plaque formation in mouse models unless they are "activated" by drugs or immunotherapy or replaced by fresh macrophages. Whether this applies to humans, too, remain
COMMENT A very interesting finding, indeed! saak.ovsepian 0
COMMENT This study is most interesting. It gives strong evidence that manipulation of the innate immune system is an important therapeutic target for AD. The authors have shown that stimulation of innate immunity via TLR9 leads to reduction in both Aβ and tau-rel
COMMENT This is a very interesting concept. Almost three decades ago, we postulated the same hypothesis, based on histologic analysis of aged brains, demonstrating a blood brain barrier (BBB) breakdown and leakage of serum proteins in aged (but not young) human b
COMMENT The study by Hill et al. is a beautiful illustration of how structure predicts function. As Dr. Attwell has pointed out, a primary controversy here is a difficulty in identifying cells that reside at the junction between arterioles and capillaries. We rec
COMMENT This is an excellent summary to an already successful meeting. Kudos to Alzforum for showing us the art of writing a powerful summary. Batous_148501 0
COMMENT It is interesting, and appers logical, that NfL levels correlate better with intracellular than with extracellular pathology. saido 0
COMMENT I want to say "thanks" to scientists for developing tools that can identify people at greatest risk for the disease, and expedite their recruitment. This is great work. maryjsmith350_213486 0
COMMENT Following up on Jeanne's request for reminiscences, I recall that Allen's discussion with song and dance was entertaining and informative. Steve Younkin was there, too. I remember Dale showing a civil war picture and pointing to a gun and statin
