Hiroshi Mori on Transferrin C2, metal binding and Alzheimer's disease.

COMMENT As the association between TFC2 and AD is significant, metal-related metabolic abnormality is an interesting factor. 0 mori

Hiroshi Mori on Modified-peptide inhibitors of amyloid beta-peptide polymerization.

COMMENT D-amino acyl analogue peptide acid (PPI-433) may be able to be a therapeutic reagent. Such a trial is useful and welcome. 0 mori

Nikolaos K. Robakis on Senile dementia with tangles (tangle predominant form of senile dementia).

COMMENT This is an interesting paper, because it illustrates that you can have clinical dementia of the Alzheimer disease type, without neuritic plaques. It would be interesting to see if these patients have high levels of intracellular amyloid. 0 nikos.robakis

Paul Coleman on Cyclooxygenase 2 RNA message abundance, stability, and hypervariability in sporadic Alzheimer neocortex.

COMMENT The role of the COX genes may be quite important in AD, not only from the point of view of an inflammatory cascade, but also in relation to synaptic activation. It would be of interest to determine whether the signal was neuronal, glial or both. Additiona

Benjamin Wolozin on Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein.

COMMENT Potential therapeutic target in AD. 0 bwolozin

Paul Coleman on Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

COMMENT Another bit of the puzzle that adds experimental analysis of a potential interaction- a neccessary consideration in view of the large number of potential interactions of APO E and in the AD brain. 0 Paul_Coleman

Paul Coleman on Circulating autoantibodies to neuronal and glial filament proteins in autism.

COMMENT No quantitative data in the abstract to allow any reasonable comment. 0 Paul_Coleman

Richard Mayeux on Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.

COMMENT Potential source for amyloid binding at the cellular level. 0 rpm2

Paul Coleman on Chronic (-) deprenyl administration increases dendritic arborization in CA3 neurons of hippocampus and AChE activity in specific regions of the primate brain.

COMMENT If this work can be replicated it would provide an interesting insight into a mechanism of action of deprenyl. 0 Paul_Coleman

Hiroshi Mori on Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

COMMENT Association of upregulated C1q with amyloid plaque in Tg mice is worth emphasizing because it has been established to be in AD patient. Thus immunoresponse such as complement must play an important role in amyloid burden. 0 mori

Paul Coleman on Expression of the alpha3 nicotinic receptor subunit mRNA in aging and Alzheimer's disease.

COMMENT No significant difference in the expression of the alpha 3 mRNA, either qualitative or quantitative, was found between Alzheimer's individuals and controls in any of the analysed areas 0 Paul_Coleman

Edward Koo on Imaging hippocampal function across the human life span: is memory decline normal or not?

COMMENT Another way to tell aging from pathology (ad and other neurodegenerative conditions?) 0 edkoo

Paul Coleman on Ubiquitin, cellular inclusions and their role in neurodegeneration.

COMMENT On the basis of the abstract of this article it appears the authors assume that inclusions of ubiquitinated proteins is harmful rather than innocent by-products or attempts of the cell to deal with pathological processes. The assumption that seem to be ma

Edward Koo on Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.

COMMENT Even for Huntington's disease, it's a "use-it-or-lose-it" situation. 0 edkoo

Hiroshi Mori on Mechanism of action of antiinflammatory drugs.

COMMENT Anti-inflammatory drugs beside anti-oxicidant or steroid reagents are interesting because they are potent drugs to cure AD patients. This comes from clinical demand and from drug developer. The basic studies is requested to do more. 0 mori