Benjamin Wolozin on Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

COMMENT Important information on how Abeta is eliminated. 0 bwolozin

Carl Cotman on The effects of additional pathology on the cognitive deficit in Alzheimer disease.

COMMENT Interesting hypothesis [that in AD combined with cerebrovascular disease, the total plaque density makes a significant contribution to cognitive deficit, while NFTs do not.] 0 cwcotman

Paul Coleman on Diabetes and dementia in long-term care.

COMMENT Interesting from the point of view of issues regarding potential relationship between metabolic status and AD. 0 Paul_Coleman

Benjamin Wolozin on Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

COMMENT Important clarification in an ongoing debate. 0 bwolozin

Paul Coleman on Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration.

COMMENT Another study with implications for cell cycle-relayed genes in AD. 0 Paul_Coleman

John Olney on Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

COMMENT See my remarks on the Barger & Mattson review. 0 OlneyJ

Hiroshi Mori on Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples.

COMMENT Racial comparison of ApoE alleles will provide some information of molecular mechanism of the disease etiology. 0 mori

Hiroshi Mori on Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

COMMENT This paper shows that cholesterol is a key for APP metabolism to produce A-beta. This may be relevant to the function of ApoE. 0 mori

Hiroshi Mori on ApoE polymorphism in Polish patients with Alzheimer's disease.

COMMENT It is important to see the ApoE allelic frequency of AD patients in various ethnic groups. 0 mori

Hiroshi Mori on The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.

COMMENT Apo e4 was not found to be a risk factor for frontotemporal dementia (FTD) in this paper but still remains to be studied further to reach the final conclusion. 0 mori

Carl Cotman on The deterioration of semantic networks in patients with Alzheimer's disease: a cross-sectional study.

COMMENT Interesting 0 cwcotman

Paul Coleman on Aluminum but not iron treatment induces pro-oxidant events in the rat brain.

COMMENT These data appear to be at some variance with other data in the literature. 0 Paul_Coleman

Nikolaos K. Robakis on Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

COMMENT This report deserves further attention as it suggests for the first time that soluble Ab 1-40 may correlate closer to AD than either Ab1-42 or NFTs. 0 nikos.robakis

Hiroshi Mori on Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.

COMMENT The effect of PS1 mutation on amyloid is significant. Little concern was paid to amyloid speceis in the insoluble fraction including intracellular beside the soluble fraction. This paper gives us further knowledge to understand the PS1 function in cells.

Hiroshi Mori on Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide.

COMMENT It is interesting to see the relationship between immuno response and amyloid plaque fomation. Evidence is not enough to discuss the etiology but this paper is one of studies on this route. 0 mori