Elliott Mufson on A computational model of the progression of Alzheimer's disease.

COMMENT Interesting. 0 emufson

Benjamin Wolozin on Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?

COMMENT Increasing data implicates iron as one of the toxins that predisposes to Parkinson's disease. This is particularly important because iron stimulates synuclein aggregation (Ostrerova, J. Neuroscience, 2000). This study provides a closer link between i

Hiroshi Mori on Wide range of disease onset in a family with Alzheimer disease and a His163Tyr mutation in the presenilin-1 gene.

COMMENT This is very interesting because of the possible occurrence of an unknown genetical factor which may interfere with the onset of the disease caused by the H163Y mutation of PS-1 at least in this family. The story may come from an analogy of a factor to re

Elliott Mufson on Apolipoprotein E and Alzheimer's disease: a review of recent studies.

COMMENT Useful review. 0 emufson

Hiroshi Mori on An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells.

COMMENT The author finds two major protein bands with Mr 53 and 116 kDa which may be important if they are associated with AD pathology. 0 mori

Hiroshi Mori on Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect?

COMMENT ERT is the most potent therapy and must be sudied with different viewpoints and more cases. This study is one of such trials and expected to expand [our understanding] more. 0 mori

Hiroshi Mori on Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

COMMENT This is certainly interesting for the possible clinical treatment as well as to see a mechanism to produce Abeta in relation of cholesterol and apo E function. 0 mori

Hiroshi Mori on Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan.

COMMENT NanoVan, a novel staining reagent, maybe attractive to distinguish different PHF structure in various disease. 0 mori

Benjamin Wolozin on On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.

COMMENT Increasing evidence suggests that elements of the cholesterol pathway regulate Abeta production. This increases the importance of understanding cholesterol metabolism and trafficking in the brain. The discovery of disease related changes in cholesterol me

Hiroshi Mori on Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

COMMENT It proves clearly that melatonin is a neurotransmitter which disturbs in AD brain. 0 mori

John Hardy on Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

COMMENT Clearly of practical relevance to therapy. 0 J.Hardy

Benjamin Wolozin on Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

COMMENT Genes causing AD are clearly important. 0 bwolozin

Hiroshi Mori on Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid precursor protein secretion and heparin binding to beta-amyloid peptide.

COMMENT This study on heparin is expected to further our understanding of the interaction with amyloid and has possible implications for a clinical therapy. 0 mori

Hiroshi Mori on The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.

COMMENT It is interesting to see PS-1 in brain tissue. This shows the complex formation of PS1 by ultracentrifugation. The data may contribute to the study of PS1 binding proteins. 0 mori

Benjamin Wolozin on A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

COMMENT Important animal model of AD. 0 bwolozin