11597 RESULTS
COMMENT This study suggests a novel mechanism by which NSAIDs might be protective in AD, and a potentially novel and selective mechanism for lowering Ab42 production. This is important because Ab42 is thought to be a critical factor initiating Ab aggregation.-- B
COMMENT This is an important study for two reasons. First, it provides a beautiful example of the kind of work needed to accurately characterize behavioral changes in transgenic mice. The inclusion of details of task and performance data, as well as possible limi
COMMENT Abnormal translation of transcripts has been reported for APP, and also for ubiquitin. This significance of these +1 proteins is unknown, but this interesting article shows that they can be toxic. When judging this work though, it is important to remember
COMMENT Another mechanism of UBB+1 activity in AD?-- Eddie Koo 0 edkoo
COMMENT "This paper presents a fascinating, two-part hypothesis. It suggests that presenilin-1 is necessary for neurogenesis in the dentate gyrus of mice that have been stimulated by exposure to an enriched environment. It goes on to propose that a biologica
COMMENT The benefits of melatonin have been touted for some time. It is a potent anti-oxidant that crosses the blood brain barrier. It can be taken clinically, as a neutraceutical, although high doses of melatonin cause depression. Dr. Pappola's team has bee
COMMENT Because nicastrin is part of the gamma-secretase complex, understanding its function is of great importance. Nicastrin was recently shown to have sequence homology to aminopeptidases. This current report addresses this issue and demonstrates that nicastri
COMMENT Despite intensive study the functions of APP are unknown, however an increasing number of experiments are identifying functions of APP. This paper is interesting because it identifies a function that appears to be dependent on APP which, if true, would be
COMMENT The study by DeKosky does not allow for conclusions about whether or not the cholinergic deficit is present at early stages of AD. The data show that there are differences in ChAT activity between a "no cognitive impairment" (NCI) group and a &q
COMMENT This study is important as it shows that at least at the level of the enzyme choline acetyltransferase, that there is not a decrease in this cholinergic marker until relatively late in the clinical course of Alzheimer's disease. While there may still
COMMENT Nordihydroguaiaretic acid (NDGA) may be posotively considered as another therapeutic or diagnostic tool for AD. Based on current issue, an interest is evoked on the effect of NDGA on non-fibrillar Abeta but oligomeric Abeta. 0 mori
COMMENT The Verfaillie paper reports the identification of pluripotent adult stem cells, which may serve as an alternative to embryonic stem cells as transplant material for cell replacement therapy. Although the paper's title refers to this cell as equivale
COMMENT Reply by Michael Wolfe As Sam Sisodia and Bart De Strooper point out in their comments, it is true
COMMENT Reply by Hui Zheng Dr. Sisodia challenged our data that hPS1D257A is negative in Notch and AβPP processing and Aβ peptides production in vivo by suggesting it is due to the low levels of expression by the human Thy-1 promoter. We argue against this interp
COMMENT Reply by Hui Zheng Dr. Sisodia challenged our data that hPS1D257A is negative in Notch and AβPP processing and Aβ peptides production in vivo by suggesting it is due to the low levels of expression by the human Thy-1 promoter. We argue against this interp
