Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 2001 Dec 11;40(49):14995-5001. PubMed.

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  1. The benefits of melatonin have been touted for some time. It is a potent anti-oxidant that crosses the blood brain barrier. It can be taken clinically, as a neutraceutical, although high doses of melatonin cause depression. Dr. Pappola's team has been investigating another potentially important property of melatonin - it's ability to inhibit Ab aggregation. This is an interesting article that furthers their prior observations by demonstrating the ability of melatonin to inhibit Ab aggregation induced by apoE. -Benjamin Wolozin.

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