11614 RESULTS
COMMENT We are a research group from Bavaria and wondered what might have happened to the ancestors and descendants of Alzheimer’s patient Johann F. He is unique because his pathology showed plaques but no tangles, and we are interested in the genetics of "p
COMMENT This is a very interesting finding that suggests a direct link between cholesterol metabolism and Alzheimer's disease. 0 bwolozin
COMMENT Also, please see the following comments related to this article: Alzheimer's disease and
COMMENT ...and suggest readers to get further notes in the following contributions: Alzheimer's disease and amyloid beta protein Koudinov AR et al. Science online, Published 25 June 2002; Amyloid hypothesis: summer 2002 and 8th International Conference on Alz
COMMENT However, it would be unipolar not to mention the following contributions related to the subject under discussion: Alzheimer's disease and amyloid beta protein Koudinov AR et al. Science online, Published 25 June 2002; Amyloid hypothesis: summer 2002
COMMENT In my view this article is misleading from the very begining, i.e. the title statement on "The emerging role of oligomeric assemblies". We had an opportunity to provide evidence in support of our arguments. Please see the following contributions
COMMENT This manuscript is very similar to ours, which we submitted to a major journal, where it has been held for more than 9 months! Anyway, the results are very interesting. They are consistent with and support our recent discovery made in collaboration with M
COMMENT Reply to Dr. Exley I have to apologize to Dr. Exley for three reasons. First, I wrote my comments
COMMENT Looks like the discussion today could be interesting. I would like to respond to the first comment
COMMENT The AD11-transgenic mouse exhibits a progressive neurodegenerative phenotype induced by expression of anti-NGF antibodies, which resembles some key features of human Alzheimer’s disease and provides further support for the relationship between NGF and AD.
COMMENT The comment posted by Professor Saido concerning the degradation of Aβ by proteases, specificially
COMMENT Reply by Malcolm Leissring Dr. Kurochkin's correctly notes that IDE does not contain a signal peptide. Surprisingly, this is true for a large number of zinc metalloproteases, including neurolysin (EC 3.4.24. 15), thimet oligopeptidase (3.4.24.16), an
COMMENT I would like to comment regarding the role of insulin-degrading enzyme (IDE) in degradation of
COMMENT I apologize for not being able to participate in the live discussion because of the time difference. The basic philosophy that we stood on when we used an in vivo paradigm, in which we injected internally radiolabeled synthetic Aβ42 into the hippocampus o
COMMENT Serag et al. report the results of site-directed spin labeling (SDSL) studies of inter-residue distances in native and amyloid-associated forms of transthyretin (TTR). TTR is associated with a number of amyloidoses, including senile systemic amyloidosis a
