11524 RESULTS
COMMENT This study uses antibody labeling and cryogenic electron microscopy to propose a model of lipidated apoE, the major functional form of this important apolipoprotein. Currently we have atomic structures of lipid-free, full-length modified human apoE and it
COMMENT As far as I know, this is the first evidence supporting that Alzheimer’s (and not just CAA) is transmissible in humans. If Alzheimer’s were to be transmissible, that would certainly open up a range of questions and concerns, including whether other, more
COMMENT The Collinge group has performed a measured, thoughtful, and careful report of dementia following iatrogenic exposure of people to pituitary extracts that contained Aβ seeding activity. The story is compelling to the extent that the group of patients were
COMMENT If self-replicating protein aggregates are the trigger for Alzheimer's disease, then the disease must in principle be transmissible. It is as simple as that. After the transmissibility of the pathology has been demonstrated in animals and humans, the
COMMENT Iatrogenic Alzheimer’s disease: a medical misadventure? Premised on our current understanding of the continuum of pathogenic changes in AD evolution, the U.K. National Prion Monitoring Cohort (NPMC) now reports eight cases of likely young-onset (38-55 yea
COMMENT The study is extremely interesting on the hot topic of potential transmission of Aβ in similar fashion as prion protein. The advent of acquired “mad cow” disease led to new standards of instrument handling when CJD is suspected. This has arguably led to s
COMMENT This very interesting paper is, as far as I know, the first demonstration of potential iatrogenic AD; previous cases had pointed to iatrogenic CAA. As cases are extremely rare, I think more research is warranted. The findings are not entirely surprising g
COMMENT This carefully considered, well-argued analysis of a small case series strongly suggests that iatrogenic transmission of Aβ in the course of human cadaver-derived pituitary growth hormone replacement therapy can induce not only CAA and diffuse Aβ plaques
COMMENT This is a very thorough report on a group of patients who received human cadaveric pituitary-derived growth hormone containing Aβ seeds in childhood for variable conditions and developed early onset of dementia with AD-like features in their 40s and 50s.
COMMENT This interesting report asks the critical important question, based on previous data in human and mice, of finding clinical cases of iatrogenic AD in cadaveric pituitary-derived growth hormone recipients beyond the reports of Aβ deposits in brains of indi
COMMENT This work continues the clinical follow-up of a U.K. cohort of at least 1,848 individuals who had been treated during childhood with cadaver-derived growth hormone (Swerdlow et al., 2003). The cohort has emerged as an invaluable tool to allow a new glimps
COMMENT The carefully presented observations by Banerjee et al. show that it is likely that Alzheimer pathology can be transmitted iatrogenically. From a clinical perspective, I hope that the lay press doesn’t over-react to this finding because the practical risk
COMMENT This is a very important and impactful study providing first convincing evidence that AD can be transmitted in humans and that the incubation time is around 35 years. I am missing a little the evaluation of the findings in a wider epidemiological context:
COMMENT Genetic variation at the TMEM106B locus is a massively under-appreciated risk factor for dementia, with a large impact on public health. TMEM106B variance was identified as a genetic modifier of dementia risk in the context of FTLD/FTD, as re-emphasized w
COMMENT As we continue to struggle with the challenges of treating CAA-RI, the potential role of immunosuppressive therapy emerges as a critical area of focus. For high-risk groups undergoing treatment with Leqembi, particularly those identified as probable cases
