11524 RESULTS
COMMENT Apolipoprotein E (APOE) is a multifunctional protein crucial for maintaining lipid homeostasis and metabolism. Certain APOE polymorphisms increase susceptibility to a wide spectrum of diseases in humans, including coronary and peripheral vascular disease,
COMMENT CXCR3 gene along with CXCR3 expression in CD8+ TEMRA cells in AD patients. As the authors comment, CD8+
COMMENT Cognitive decline associated with aging is often the harbinger of an underlying neurodegenerative process ultimately leading to Alzheimer’s disease. Genetic studies have found strong associations between variants in immune genes and AD, but neuroscientist
COMMENT In recent decades, substantial strides have been made in unraveling the genetic factors and biological mechanisms underlying Alzheimer’s disease, with a primary focus on microglia as the brain's resident immune cells. However, it is now widely recogn
COMMENT In this paper, the authors from the laboratory of Dag Sehlin, and coworkers, provide an interesting update on the properties of the Uppsala APP mutation in transgenic mice (Pagnon de la Vega, et al., 2024). A previous report described that the Uppsala mut
COMMENT This was an interesting paper from Uppsala, following up their previous report of the Uppsala mutation (Pagnon de la Vega et al., 2021), now modeling it in transgenic mice. The most striking observation from the tg-UppSwe mice, compared to tg-ArcSwe or tg
COMMENT This interesting study examined mouse and human perivenous physiology, which has been a relatively overlooked area of investigation. The authors found that dynamic changes occur in both species within the spaces around veins, and further depict immune cel
COMMENT The authors provide an important cellular and functional description of the arachnoid barrier cell layer that explains how it is simultaneously capable of separating and adjoining compartments (namely, the subarachnoid space and dural interstitium), there
COMMENT This new work shows extensive anatomical and functional evidence that spots where bridging veins cross from the leptomeninges to the dura are entry-exit points for small and large molecular weight tracers. This is in contrast to the arachnoid barrier laye
COMMENT This major scientific study coming from the Kipnis lab shines light onto the architecture of the mammalian meninges, and its crucial roles in mediating the molecular and cellular communication between the brain, its border tissues, and the periphery. Desp
COMMENT The extent of novel anatomical observations at the leptomeningeal-brain interface coming out of this lab is astounding. This important blood-brain border has been overlooked, mostly because of lack of tools to dissect its anatomy and cellular and function
COMMENT Smyth et al. present several new observations about the nature and function of the meningeal layers surrounding the brain. Using transcriptomic data, they generated new mouse models to visualize and study anatomical structures that function as routes acro
COMMENT This paper is of great importance. It potentially represents a breakthrough in our comprehension of how substances in the CSF of the subarachnoid space communicate with the dura mater, which houses lymphatic vessels. It introduces fresh insights into crit
COMMENT Over the last 20 years, it became evident that adaptive and innate immune cells play a key role in lifelong brain plasticity and protection in health, with far-reaching implications for brain aging and diseases. This transformative understanding raised qu
COMMENT Several studies have already shown that Aβ and tau pathologies are transmitted after iatrogeniuc contamination with Aβ/tau-contaminated compounds (Lauwers et al., 2020). The functional impact of such transmission was, however, still unclear as most subjec
