PAPER Zheng Y, Yang J, Li X, Qi L, Zheng Z, Kong J, Zhang G, Guo Y

Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration.

Neurobiol Dis. 2025 Mar 4;208:106862. Epub 2025 Mar 4 PubMed.

Fragments of Tau’s Microtubule Binding Region Mess with Synapses

RESEARCH NEWS 2025-03-06 Research News When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they encounter along the way, according to a p

Kanta Horie on Fragments of Tau’s Microtubule Binding Region Mess with Synapses

COMMENT This study investigated what tau species are capable of inducing synaptotoxicity, by measuring LTP in rats injected with AD brain extracts or with secretomes of iPSC-derived neurons from individuals with Down’s syndrome. The study design includes the immu

PAPER Ondrejcak T, Hu N-W, Coode E, Campbell T, Corbett GT, Doykov I, Mills K, Walsh DM, Livesey FJ, Rowan MJ, Klyubin I

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

bioRxiv2025.02.21.639417 .

PAPER Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SH, Goedert M

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W.

Nat Struct Mol Biol. 2025 Mar 5; Epub 2025 Mar 5 PubMed.

Can Autoimmunity Spark Alzheimer’s Disease?

RESEARCH NEWS 2025-03-06 Research News Alzheimer’s may be, at least in part, a disease of the immune system. Evidence supporting this comes from the study of genetics, infectious diseases, and the molecular machinations of the innate and adaptive immune systems in the brain. Now,

Michael Guo on Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.

COMMENT The authors leverage cutting-edge tools to large sequencing datasets in order to examine Variable Number Tandem Repeats, which, given their repetitive nature, have been traditionally very challenging to study at scale. The authors find multiple VNTRs that

PAPER Heath A, McNerney MW, Yesavage J

Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease.

Neurol Genet. 2025 Apr;11(2):e200241. Epub 2025 Feb 14 PubMed.

Donald Weaver on Can Autoimmunity Spark Alzheimer’s Disease?

COMMENT This paper contributes significantly to our understanding of the role of dysregulated adaptive immunity in the pathogenesis of Alzheimer’s disease. It represents a significant body of knowledge regarding how autoimmunity may contribute to AD risk. The aut

Rebecca Wallings

Indiana University
United States

Elaine Lim on Can Autoimmunity Spark Alzheimer’s Disease?

COMMENT I believe this is among the first, if not the first, large-scale, systematic study of electronic medical records (EHR) testing associations between Alzheimer’s and 26 autoimmune diseases. I found the paper super interesting because several studies have re

Chun Keung Shum