296 RESULTS
RESEARCH NEWS 2025-03-06 Research News When under stress, neurons crank out tau fragments, and many scientists blame this for the propagation of tangle pathology in Alzheimer’s disease. The fragments also directly compromise synapses they encounter along the way, according to a p
COMMENT This study investigated what tau species are capable of inducing synaptotoxicity, by measuring LTP in rats injected with AD brain extracts or with secretomes of iPSC-derived neurons from individuals with Down’s syndrome. The study design includes the immu
PAPER Ondrejcak T, Hu N-W, Coode E, Campbell T, Corbett GT, Doykov I, Mills K, Walsh DM, Livesey FJ, Rowan MJ, Klyubin I
PAPER Qi C, Lövestam S, Murzin AG, Peak-Chew S, Franco C, Bogdani M, Latimer C, Murrell JR, Cullinane PW, Jaunmuktane Z, Bird TD, Ghetti B, Scheres SH, Goedert M
RESEARCH NEWS 2025-03-06 Research News Alzheimer’s may be, at least in part, a disease of the immune system. Evidence supporting this comes from the study of genetics, infectious diseases, and the molecular machinations of the innate and adaptive immune systems in the brain. Now,
COMMENT The authors leverage cutting-edge tools to large sequencing datasets in order to examine Variable Number Tandem Repeats, which, given their repetitive nature, have been traditionally very challenging to study at scale. The authors find multiple VNTRs that
PAPER Heath A, McNerney MW, Yesavage J
COMMENT This paper contributes significantly to our understanding of the role of dysregulated adaptive immunity in the pathogenesis of Alzheimer’s disease. It represents a significant body of knowledge regarding how autoimmunity may contribute to AD risk. The aut
Indiana UniversityUnited States
COMMENT I believe this is among the first, if not the first, large-scale, systematic study of electronic medical records (EHR) testing associations between Alzheimer’s and 26 autoimmune diseases. I found the paper super interesting because several studies have re
