Brain Organoids Summer Symposium

CONFERENCE 2025-06-11 00:00:00-2025-06-13 00:00:00 Bilbao, Spain 11 &#x2013 13 June 2025 View Conference Website 0

Rashi Mehta on Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?

COMMENT It is interesting that the brain vasculature was found to be exceptionally sensitive to mucin-type-O-glycan perturbations. Time dependency of the effects of the mucin protease StcE on the endothelial glycoprotein layer and barrier function is also relevan

APP L723R

MUTATIONS APP 27264077 GRCh37/hg19 T G 25891765 GRCh38/hg38 T G Exon 17 Coding Increased Aβ42 and decreased Aβ40 levels resulting in an increased Aβ42/Aβ40 ratio in cells. Unknown. L723R Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant

Malu G. Tansey, Rebecca Wallings on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT A wealth of literature demonstrates that the arsenal of inflammatory responses in males is radically different from that in females. If one acknowledges that females experience giving birth, and that pain tolerance is regulated by inflammatory signaling l

Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

RESEARCH NEWS 2025-03-07 Research News Despite growing recognition of the importance of the peripheral immune system in neurodegenerative disease, little is known about how these blood cells change in Alzheimer’s and Parkinson’s diseases. In the February 25 Nature Communications,

Enrico Glaab on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT This study makes a significant contribution to our understanding of sex-specific immune signatures in neurodegenerative diseases. The authors have created a comprehensive single-cell atlas of peripheral blood mononuclear cells from patients with Alzheimer

APP N660Y

MUTATIONS APP 27269971 GRCh37/hg19 rs770773038 A T 25897659 GRCh38/hg38 A T Exon 16 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 25.8). Unknown. N660Y Alzheimer's Disease: Not ClassifiedProbable VaD Data on the carrier(s) of t

PAPER Coleman MP, Höke A

Programmed axon degeneration: from mouse to mechanism to medicine.

Nat Rev Neurosci. 2020 Apr;21(4):183-196. Epub 2020 Mar 9 PubMed.

PAPER Sambashivan S, Freeman MR

SARM1 signaling mechanisms in the injured nervous system.

Curr Opin Neurobiol. 2021 Aug;69:247-255. Epub 2021 Jun 25 PubMed.

Biocuration Scientist

JOB 2025-03-07 Employer AlzForum Foundation Inc. Contact Apply here. Description The biocuration scientist is responsible for the ongoing curation of scientific databases and directories in the Alzforum website (www.alzforum.org).  Alzforum provides a high-quality scien

NB-4746

THERAPEUTICS Nura Bio™ Inc. Small Molecule Other In August 2023, Nura Bio began Phase 1 with an ascending-dose safety trial in 66 healthy volunteers. Single doses of 50, 100, 175, 300, 450, and 600 mg, or 10 days of repeated dosing were compared to placebo. Besides sa

Russell Swerdlow on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT A PET ligand that reveals oxidative stress in the human brain will facilitate work within the AD research field on a number of levels. It will help investigators get a glimpse into oxidative stress in the brains of AD patients. From there, investigators c

Aoife Murray

, United Kingdom

PAPER Wen S, Ju Z, Wang Y, Zuo CT, Sun X, Zheng T

FRET Nanosensor Based on DNA Tetrahedron for Visualizing PLD3 Fluctuation in Mouse Models of Alzheimer's Disease.

ACS Appl Mater Interfaces. 2025 Mar 5;17(9):13461-13470. Epub 2025 Feb 19 PubMed.

PAPER Ludolph A, Klose V, Dreyhaupt J, Del Tredici K, Braak H

The deltoid muscle and the pattern of paresis in ALS.

J Neurol. 2025 Mar 6;272(3):253. PubMed.