PAPER Bartrés-Faz D, Marchant NL
SEARCH RESULTS
1768 RESULTS
PAPER Borrego-Ruiz A, Borrego JJ
The role of the gut microbiome in Alzheimer's disease pathophysiology.
Curr Opin Neurol. 2025 Apr 1;38(2):157-162. Epub 2025 Feb 7 PubMed.Franklin Tseng on Leqembi Maintenance Dosing Approved in the U.S.
COMMENT The maintenance dose is hugely welcome, but we need FDA approval of the epipen. TAAAFT_407236 0
David Weisman on Leqembi Maintenance Dosing Approved in the U.S.
COMMENT As a practical matter, this is wonderful news for our practice. We currently have about 10 people who will adopt this dose and many to follow. This frees us up to accommodate new doses, help more people, and provides a goal which is sure to help discussio
Céline Bellenguez, Julie Le Borgne on Blame Mom? Maternal X Chromosome Worsens Memory
COMMENT By showing that the maternal X-chromosome (Xm) affects cognition in female mice, this study highlights that sex differences in aging cognition could be partly explained by skewed inactivation of the X-chromosome toward Xm. Next steps would be to assess wh
Expunging Microglial Lipid Droplets Boosts Phagocytosis
RESEARCH NEWS 2025-02-07 Research News In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in these cells restores their capacity to e
Pinar Ayata on Expunging Microglial Lipid Droplets Boosts Phagocytosis
COMMENT This study contributes to a growing body of research on the role of microglial lipid metabolism in Alzheimer’s disease. Important studies from the labs of Tony Wyss-Coray, Li-Huei Tsai, Mathew Blurton-Jones, Gaurav Chopra, Erik Musiek, and many others sho
Laura Piccio on Expunging Microglial Lipid Droplets Boosts Phagocytosis
COMMENT This study investigates the role of the protein FIT2, a key protein in lipid droplet biogenesis, in LD accumulation within microglia and BAMs in an AD mouse model. They show that LDs accumulate with age and AD progression in the two cell types in the CNS
The Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging
GRANT Friday, February 7, 2025- 2:30pm American Federation for Aging Research (AFAR) Each scholarship is $5,000. No indirect costs or overhead are allowed. April 15, 2025. https://www.afar.org/grants/afar-scholarships 16 Apr 2025
Kimberley Bruce on Expunging Microglial Lipid Droplets Boosts Phagocytosis
COMMENT Although the sequestering of lipids within intracellular lipid droplets protects against lipid oxidation, excess lipid droplet accumulation is associated with aging and disease. In AD, microglia accumulate excess lipid droplets, which leads to reduced fun
Kimberley Bruce
University of Colorado Anschutz Medical Campus
Tony Wyss-Coray, Andy Tsai on Expunging Microglial Lipid Droplets Boosts Phagocytosis
COMMENT Reducing microglial lipid load enhances Aβ phagocytosis in an Alzheimer’s disease mouse model Wu and co-authors investigate the role of lipid-droplet-accumulating microglia (LDAM) and border-associated macrophages (BAMs) in an APP-KI model, which harbors
PAPER Zazo Seco C, Castells-Nobau A, Joo SH, Schraders M, Foo JN, van der Voet M, Velan SS, Nijhof B, Oostrik J, de Vrieze E, Katana R, Mansoor A, Huynen M, Szklarczyk R, Oti M, Tranebjærg L, van Wijk E, Scheffer-de Gooyert JM, Siddique S, Baets J, de Jonghe P, Kazmi SA, Sadananthan SA, van de Warrenburg BP, Khor CC, Göpfert MC, Qamar R, Schenck A, Kremer H, Siddiqi S
A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy.
Dis Model Mech. 2017 Feb 1;10(2):105-118. Epub 2016 Dec 15 PubMed.Current Filters
- Date Range : Feb 2025 to Mar 2025 x