8 RESULTS
COMMENT Our study investigated the mechanism of inhibition of tau aggregation by methylene blue and its metabolites, azure A and B, when starting from the tau monomer—that is, the conformation that is able to bind to microtubules. NMR spectroscopy together with m
COMMENT This highly interesting study by Eisenberg and colleagues reveals the atomic resolution structure of two short segments of α-synuclein in a fibril-like state. Using micro-electron diffraction. the structure of an 11-residue segment of α-synuclein, which i
COMMENT Cristian Lasagna-Reeves and colleagues in the lab of Huda Zoghbi show—using a variety of model systems for tauopathy—that the serine/threonine-protein kinase Nuak1 plays an important role in neurotoxicity associated with the protein tau. In addition, they
COMMENT This study represents a breakthrough in our understanding of the pathological conformation of the Alzheimer-related protein tau. In a unique manner it combines preparations of insoluble protein deposits from a patient with Alzheimer’s disease, which were
COMMENT Liquid-liquid phase separation of intrinsically disordered proteins has been implicated as a key process for the regulation of dynamic biological processes and has been linked to neurodegenerative diseases such as frontotemporal dementia and amyotrophic l
COMMENT The Nobel Prize for cryo-electron microscopy honors the development of and recent breakthroughs that have been achieved by this extremely powerful structural biology technique. Currently there is hardly a week in which an exciting cryo-EM structure of a c
COMMENT The study by McInnes et al., together with a previous study from the same group (Zhou et al., 2017), suggests a very interesting mechanism of tau-mediated neurotoxicity. The proposed mechanism is based on a direct interaction of tau with synaptic vesicles
COMMENT This highly interesting study supports an important role of sumoylation as a post-translational modification that solubilizes aggregation prone proteins. The study focuses on SUMO2, and it will be interesting to see how modification by SUMO2 compares to m
