15 RESULTS
COMMENT This is a very interesting and thorough study investigating astrocyte heterogeneity in Alzheimer’s disease. Astrocytes are highly diverse in the brain, with several transcriptional and morphological subtypes. Serrano-Pozo and colleagues elegantly profile
COMMENT This study is very exciting and opens new ways to assess cell heterogeneity in the brain that were not possible before. We have, and are, learning a lot from single-cell transcriptomes, and these new technologies would allow us to dive more deeply into th
COMMENT This exciting and thought-provoking work by Scott-Hewitt et al. uncovers a new intraneuronal function for the microglial secreted protein C1q. The authors performed C1q co-immunoprecipitation from synaptosomes isolated from developing, young adult, and ad
COMMENT The study from Kedia et al. examines the role of brain-infiltrating CD8+ T cells in promoting white-matter damage. Using two models of Alzheimer’s disease (5XFAD and AppNL-G-F), removing CD8+ T cells reduced myelin abnormalities, and had positive effects
COMMENT The two articles published back-to-back propose the exciting therapeutic concept that microglial transplantation can potentially rescue brain defects induced by the congenital lack of microglia. Both papers agree that the lack of microglia in adult mice r
COMMENT This is very interesting work, as it dives into the plethora of receptors that control microglial function. For very good reasons, the field has focused extensively on some specific molecules, such as TREM2 or CD33, but microglia express a vast diversity
COMMENT This is a very interesting and comprehensive piece of work diving into the mechanisms of microglial-induced neuronal toxicity in the context of tauopathy. It is in line with previous work by myself (Mancuso et al., 2019) and the Holtzman lab (Shi et al.,
COMMENT This is very nice, thought-provoking work. It shows the full potential of mining existing datasets to shed light on disease mechanisms. As a biologist, I highly appreciate the work from Shih-Feng You and collaborators because it gives us much more concret
COMMENT I find this a very stimulating paper that shows the vast potential of collaborations between academics and industry. I think this is the way forward and we should foster these types of interactions. The authors describe a robust strategy to induce TREM2 a
COMMENT This is a very interesting paper. I agree that given the pivotal role of microglia in neurodegenerative disorders, strategies that aim to correct microglial functional defects are very relevant. Among those, microglial cell therapy is potentially very exc
COMMENT These are very relevant papers given the central role of microglia in Alzheimer’s disease and other neurodegenerative disease. It is also very nice to see that research performed independently and in parallel yields the same results. From a scientific poi
COMMENT This comprehensive paper goes from clinical observations and genetics to proof of concept in experimental models. One exciting thing about it: It showcases how complicated Alzheimer’s disease is. The authors describe cross talk between endothelial cells a
COMMENT The efforts of several groups that have recently applied single-cell transcriptomics to characterize microglial populations in physiology and disease have converged to the description of microglial reactive phenotypes with overlapping signatures across de
COMMENT This is an extraordinary study that provides a final piece of evidence for the causal involvement of microglia in Alzheimer’s disease. This work follows up a previous report from the same group, where the authors performed transcriptomic analysis of human
COMMENT Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease, as highlighted by several genome-wide association studies (GWAS). While the role of microglia has been extensively studied within the context of multiple Aβ mo
