20 RESULTS
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COMMENT We read the this paper (Ramakrishnan et al., 2024) with great interest and agree with others’ comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic markers in the etiology of AD (Maloney and Lahiri, 20
COMMENT Like many friends and colleagues, I was surprised and saddened to hear about the unexpected passing of Mary Jo LaDu, so untimely! Mary’s seminal contribution to the apolipoprotein (ApoE) field is well-known. I first met Mary at a Society for Neuroscience
COMMENT Despite the high likelihood that the new FDA-approved AD treatment, Lequembi, may only benefit a select group of patients, we agree that it is a timely and positive step in the right direction. We need to understand how much amyloid immunotherapy will hel
COMMENT The role of the tau haplotype in neurodegeneration is critical, and this recent work on different biological effects of haplotypes is intriguing. The H2 haplotype of the MAPT gene region of chromosome 17 has long been known to confer protection from neuro
COMMENT We were shocked and saddened to hear of the demise of Steve Wagner. As others have noted, Steve was a pillar of the AD research community and a pioneer of GSMs. We gratefully recall his significant contributions to our research years ago while we elucidat
COMMENT We would like to congratulate John Hardy for receiving the accolade of Knight Bachelor (i.e., a knighthood) as part of the New Year Honors 2022 list awarded by Queen Elizabeth II. Knighthood is generally conferred for exceptional public service, caries th
COMMENT Hats off to the authors for illumiNATing NATs. Maintaining cellular checks and balances requires multiple mechanisms. A recently reported participant to maintain tau protein homeostasis was mammalian-wide interspersed repeat (MIR) natural antisense transc
COMMENT This elegant genetic study may have identified several important genes that may protect APOEε4-carriers from, or reduce APOEε2 carriers’ protection against, Alzheimer's disease. Both findings challenge our current understanding of APOE genotype as a
COMMENT Development of an unprecedented nonhuman primate model (NHP) of familial Alzheimer’s disease (FAD) by Saido and colleagues is an outstanding accomplishment. As others mentioned on Alzforum, a familial NHP model is a significant contribution to the AD fiel
COMMENT I am profoundly saddened to learn that Peter Davies passed away. I've always had tremendous respect for Peter, both as a scientist and a person. He was an extraordinarily gifted researcher, brilliant thinker, and a man of genuine warmth and generosit
COMMENT Goedert’s group, including colleagues from Tokyo and Indiana, has made a seminal contribution to the field, and far beyond it. It is of particular note that “The three-dimensional structures look nothing like those formed by Aβ or tau fibrils, or indeed b
COMMENT The article by Ayton et al. is pivotal to our understanding of iron’s role in Alzheimer’s disease (AD) pathology and dementia. This exciting work connects another important recent research on microRNA (miR-346) to the field. Let us try to iron out the kin
COMMENT To alleviate BACE1 trials disappointment, I suggest not missing the APPointment. BACE1 inhibition should remain a viable strategy even though recently tested BACE1 inhibitors worsened cognition. We must be brave to tackle the “bumps” along the way of BA
COMMENT The recent structural studies illuminate that Pick’s disease is picky in selecting a repeat to fold into tau aggregates. Falcon and colleagues have demonstrated an exciting difference at the molecular level between Alzheimer’s disease and Pick’s disease
COMMENT To iron out a few kinks in Alzheimer’s disease field, Lumsden et al. have built an iron framework that might unite, functionally, several known mutations associated with the familial form of AD. It is timely and thought provoking. The “traditional” approa
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