15 RESULTS
COMMENT The UEF NEURO-RC, led by Mikko Hiltunen, is a truly remarkable program. We in the field have historically suffered from "biopsy envy." Unlike other diseases that have the advantage of performing detailed cellular and molecular investigations on
COMMENT What distinguishes AD-associated tauopathy from other tauopathies is accelerated active tau secretion. This process does not occur via the conventional secretory pathway but is suggested to occur via “unconventional” endolysosomal secretion; namely upon t
COMMENT I think the CMS made the right decision, except it might have been better to ask the company to run additional, required, randomized controlled trials. A limited number of patients will be able to access the drug under these conditions. Perhaps that is a
COMMENT Neurons sickened by Alzheimer’s disease secrete telltale proteins, even at the earliest stages before the sickened neurons slowly die. Neurons in general, and sick neurons in particular, utilize an “unconventional” hatch to secrete proteins, specifically
COMMENT The key questions for everyone—physicians, patients, and their families—is whether they “believe” that clearing amyloid from the brain will be beneficial and, if so, by what degree. The central problem is that, unfortunately and for now, answers to these
COMMENT This is a beautiful paper by Randy Nixon, whose group first described enlarged endosomes as a cytopathogenic feature of AD. To date, enlarged endosomes have been shown to occur via the genes that cause early onset AD in an APP dependent manner (e.g., Kwar
COMMENT In 2014, as a joint effort with the Petsko and Ringe labs, we introduced a class of drugs called “retromer pharmacological chaperones” (Mecozzi et al., 2014). Retromer’s core is a trimer, and one of the most reliable observations from the ever-growing li
COMMENT This elegant study provides proof-of-principle evidence that the cascading component of the “amyloid cascade hypothesis” can be unhinged. The study shows that a lot of amyloid plaque accumulation does not necessarily lead to tau pathology and neurodegener
COMMENT This duet of papers represents the swan song of one of the deepest thinkers into the fundamental biology of neurodegeneration, our recently departed friend Sue Lindquist, who sadly died a few months ago. The papers illustrate the magnificent creativeness
COMMENT “Where, oh where, is Aβ?” Menno Witter is a leading expert on the anatomical organization of the hippocampal formation, i.e., the entorhinal cortex plus hippocampus proper. This latest manuscript, typical of the Witter lab in its elegance and rigor, infor
COMMENT develop schizophrenia. One thing that is not commented on is whether H.M. has evidence of tau or amyloid
COMMENT This work very much concords with our PNAS paper, which found that exercise causes a selective increase in dentate gyrus CBV (Pereira et al., 2007). One thing to note is that they find that the increase in hippocampal volume correlates with exercise-induc
COMMENT The ability to visualize disease has long motivated and driven the history of Western medicine. The end of the nineteenth century represents a turning point in the ability to do so: At around the same time neuroanatomists perfected staining techniques tha
COMMENT Although little more that a decade old, fMRI already has an established pantheon of "giants in the field." Seiji Ogawa, one of these giants, was the first to observe that when rodents breathe, 100 percent oxygen-diminished contrast is observed i
COMMENT When introduced as a clinical tool in the 1980s, MRI transformed the field of clinical neuroscience. Visualizing the brain with exquisite anatomical resolution was one thing, but to accomplish this feat noninvasively, so that human subjects could be image
