Alma Mohebiany, Renzo Mancuso on T Cells in the Brain Goad Microglia to Muddle Myelin
COMMENT The study from Kedia et al. examines the role of brain-infiltrating CD8+ T cells in promoting white-matter damage. Using two models of Alzheimer’s disease (5XFAD and AppNL-G-F), removing CD8+ T cells reduced myelin abnormalities, and had positive effects