328 RESULTS
COMMENT I commend the authors for their exceptional characterization of the novel PET probe [18F]FEDV, which shows strong potential for detecting reactive oxygen species (ROS) in models of stroke and tauopathy. The validation of [18F]FEDV using dihydroethidium, t
Rush University Medical CenterUnited States
Children's Hospital of Philadelphia
Brazil
University of Eastern FinlandFinland
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, GermanyGermany
UT Health San Antonio
COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to
PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ
COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex
VIB/KU LeuvenBelgium
PAPER Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein HJ, Mettenburg JM, Yong WH, Head E, Ikonomovic MD, Ibrahim TS, Kofler JK, Alzheimer Biomarker Consortium—Down Syndrome
University of Illinois ChicagoUnited States
MUTATIONS PSEN1 73653588_73653590 GRCh37/hg19 TCT--- 73186880_73186882 GRCh38/hg38 TCT--- Exon 6 Coding Unknown, although a variant resulting in S170 deletion (DNA change unknown) resulted in an increased Aβ42/Aβ40 ratio and a decreased Aβ37/42 ratio in cells. Unkn
, Peru
