Nicolai Franzmeier, Davina Biel on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This meta-analysis by Coughlan et al. provides robust evidence across six longitudinal cohorts, showing that women accumulate tau pathology faster than men in preclinical AD. This work is of high clinical relevance, as the transition from amyloidosis to t

PAPER Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

JAMA Netw Open. 2025 Mar 3;8(3):e250562. PubMed.

Masoud Ghamari-Langroudi

United States

Meagan McManus on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I commend the authors for their exceptional characterization of the novel PET probe [18F]FEDV, which shows strong potential for detecting reactive oxygen species (ROS) in models of stroke and tauopathy. The validation of [18F]FEDV using dihydroethidium, t

Katia Lopes

Rush University Medical Center
United States

Meagan McManus

Children's Hospital of Philadelphia

Salete Lopes Ribeiro

Brazil

Tavapadon

THERAPEUTICS 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]pyrimidine-2,4-dione AbbVie Cerevel Therapeutics, LLC. Pfizer PF-06649751 CVL-751 Small Molecule Other Neurotransmitters From 2014 to 2016, Pfizer conduced Phase 1 trials of single- and

Sami Heikkinen

University of Eastern Finland
Finland

Davina Biel

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany
Germany

Eva Beckett

UT Health San Antonio

PAPER Ti Y, Liu F, Ma Y, Zhu Q, Xie C, Xia H, Chen J

Correlation of Plasma α-Synuclein with Cerebral Blood Flow in Patients with Parkinson Disease with Freezing of Gait.

Clin Lab. 2025 Mar 1;71(3) PubMed.

PAPER Guo JL, Huang TY, Zhang Z, Niu K, Gongbikai X, Gong XL, Wang XM, Zhang T

[The role of microglia activated by the deletion of immune checkpoint receptor CD200R1 gene in a mouse model of Parkinson's disease].

Sheng Li Xue Bao. 2025 Feb 25;77(1):13-24. PubMed.

PAPER Zarnowska A, Milewska M, Rokicka G, Kacprzyk K, Panczyk M, Folwarski M, Szostak-Węgierek D

Prevalence of malnutrition in patients with Alzheimer's disease- A systematic review. The call for consistent nutritional assessment methods.

Nutr Hosp. 2025 Mar 6; Epub 2025 Mar 6 PubMed.

PAPER Li T, Chen J, Xie Z, Fang J, Wu Q, Cao X, Chen Z, Wang Y, Fan Q, Wang Q, Liu J

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.

Front Pharmacol. 2025;16:1528590. Epub 2025 Feb 24 PubMed.