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PAPER Liu GS, Song Y, Yan JS, Chai YJ, Zhao YF, Ma H
Identification of enterotype for patients with Alzheimer's disease.
J Transl Med. 2025 Mar 10;23(1):299. PubMed.PAPER Li T, Chen J, Xie Z, Fang J, Wu Q, Cao X, Chen Z, Wang Y, Fan Q, Wang Q, Liu J
Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.
Front Pharmacol. 2025;16:1528590. Epub 2025 Feb 24 PubMed.PAPER Sugimoto T, Uchida K, Sato K, Yokoyama Y, Onoyama A, Fujita K, Kuroda Y, Wakayama S, Arai H, Sakurai T, J‐MINT study group
Factors associated with adherence to tablet-based cognitive training: J-MINT study.
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Broad repetitive transcranial magnetic stimulation (rTMS) of the precuneus in Alzheimer's disease: A rationale and study design.
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UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia.
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Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease.
Nat Aging. 2025 Mar 10; Epub 2025 Mar 10 PubMed.PAPER Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM
A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy.
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Insulin resistance in Alzheimer's disease: signalling mechanisms and therapeutics strategies.
Inflammopharmacology. 2025 Mar 10; Epub 2025 Mar 10 PubMed.PAPER Qaisar R, Karim A, Iqbal MS, Alkahtani SA, Ahmad F
Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.
Acta Neurol Belg. 2025 Mar 11; Epub 2025 Mar 11 PubMed.Robert Mach on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.
COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to
PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ
Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace
Int. J. Mol. Sci. 2025 . International Journal of Molecular SciencesPierre Tariot on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex
Risvodetinib
THERAPEUTICS Inhibikase Therapeutics, Inc. IkT-148009 Small Molecule alpha-synuclein Other Between February 2021 and January 2023, Inhibikase ran a Phase 1 single- and multiple-ascending-dose trial. The study enrolled 108 participants, and tested nine single doses fro
COYA 302
THERAPEUTICS Coya Therapeutics IL2 plus Abatacept Combination Other Inflammation In October 2021, an investigator-initiated, open-label study of COYA 302 began at the Houston Methodist Research Institute. The study planned to enroll 10 people with ALS, treat them ever
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