PAPER Cuní-López C, Stewart R, Okano S, Redlich GL, Appleby MW, White AR, Quek H

Exploring a patient-specific in vitro pipeline for stratification and drug response prediction of microglia-based therapeutics.

Sci Rep. 2025 Mar 10;15(1):8296. PubMed.

PAPER Liu GS, Song Y, Yan JS, Chai YJ, Zhao YF, Ma H

Identification of enterotype for patients with Alzheimer's disease.

J Transl Med. 2025 Mar 10;23(1):299. PubMed.

PAPER Li T, Chen J, Xie Z, Fang J, Wu Q, Cao X, Chen Z, Wang Y, Fan Q, Wang Q, Liu J

Ginsenoside Ro ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via the IBA1/GFAP-MAPK signaling pathway.

Front Pharmacol. 2025;16:1528590. Epub 2025 Feb 24 PubMed.

PAPER Sugimoto T, Uchida K, Sato K, Yokoyama Y, Onoyama A, Fujita K, Kuroda Y, Wakayama S, Arai H, Sakurai T, J‐MINT study group

Factors associated with adherence to tablet-based cognitive training: J-MINT study.

Alzheimers Dement (N Y). 2025;11(1):e70062. Epub 2025 Mar 10 PubMed.

PAPER Leuchter MK, Oughli HA, Durbin KA, Jackson NJ, Elashoff D, Chang TS, Corlier J, Ngo D, Matthews C, Wong D, Fogel BL, Bitan G, Leuchter AF, Vossel K, Suthana N

Broad repetitive transcranial magnetic stimulation (rTMS) of the precuneus in Alzheimer's disease: A rationale and study design.

Alzheimers Dement (N Y). 2025;11(1):e70043. Epub 2025 Mar 10 PubMed.

PAPER Wu Y, Xu R, Gasevic D, Yang Z, Yu P, Wen B, Liu Y, Zhou G, Zhang Y, Song J, Liu H, Li S, Guo Y

UK Biobank data demonstrate long-term exposure to floods is a risk factor for incident dementia.

Commun Med (Lond). 2025 Mar 10;5(1):71. PubMed.

PAPER Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo PL, Tong L, Qin S, Fuentes LA, Pinheiro-de-Sousa I, Huynh T, Sun L, Mansuri MS, Tian Z, Gan HR, Braker A, Trinh HK, Huttner A, Lam TT, Petsalaki E, Brennand KJ, Nairn AC, Grutzendler J

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease.

Nat Aging. 2025 Mar 10; Epub 2025 Mar 10 PubMed.

PAPER Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy.

Cell Discov. 2025 Mar 11;11(1):22. PubMed.

PAPER Dahiya M, Yadav M, Goyal C, Kumar A

Insulin resistance in Alzheimer's disease: signalling mechanisms and therapeutics strategies.

Inflammopharmacology. 2025 Mar 10; Epub 2025 Mar 10 PubMed.

PAPER Qaisar R, Karim A, Iqbal MS, Alkahtani SA, Ahmad F

Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.

Acta Neurol Belg. 2025 Mar 11; Epub 2025 Mar 11 PubMed.

Robert Mach on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to

PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ

Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace

Int. J. Mol. Sci. 2025 . International Journal of Molecular Sciences

Pierre Tariot on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex

COYA 302

THERAPEUTICS Coya Therapeutics IL2 plus Abatacept Combination Other Inflammation In October 2021, an investigator-initiated, open-label study of COYA 302 began at the Houston Methodist Research Institute. The study planned to enroll 10 people with ALS, treat them ever

Giulia Albertini

VIB/KU Leuven
Belgium