1779 RESULTS
RESEARCH NEWS 2025-03-07 Research News Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a study published February 18 in Proceedings o
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COMMENT It is interesting that the brain vasculature was found to be exceptionally sensitive to mucin-type-O-glycan perturbations. Time dependency of the effects of the mucin protease StcE on the endothelial glycoprotein layer and barrier function is also relevan
MUTATIONS APP 27264077 GRCh37/hg19 T G 25891765 GRCh38/hg38 T G Exon 17 Coding Increased Aβ42 and decreased Aβ40 levels resulting in an increased Aβ42/Aβ40 ratio in cells. Unknown. L723R Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant
COMMENT A wealth of literature demonstrates that the arsenal of inflammatory responses in males is radically different from that in females. If one acknowledges that females experience giving birth, and that pain tolerance is regulated by inflammatory signaling l
RESEARCH NEWS 2025-03-07 Research News Despite growing recognition of the importance of the peripheral immune system in neurodegenerative disease, little is known about how these blood cells change in Alzheimer’s and Parkinson’s diseases. In the February 25 Nature Communications,
COMMENT This study makes a significant contribution to our understanding of sex-specific immune signatures in neurodegenerative diseases. The authors have created a comprehensive single-cell atlas of peripheral blood mononuclear cells from patients with Alzheimer
MUTATIONS APP 27269971 GRCh37/hg19 rs770773038 A T 25897659 GRCh38/hg38 A T Exon 16 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 25.8). Unknown. N660Y Alzheimer's Disease: Not ClassifiedProbable VaD Data on the carrier(s) of t
PAPER Coleman MP, Höke A
PAPER Sambashivan S, Freeman MR
JOB 2025-03-07 Employer AlzForum Foundation Inc. Contact Apply here. Description The biocuration scientist is responsible for the ongoing curation of scientific databases and directories in the Alzforum website (www.alzforum.org). Alzforum provides a high-quality scien
THERAPEUTICS Nura Bio™ Inc. Small Molecule Other In August 2023, Nura Bio began Phase 1 with an ascending-dose safety trial in 66 healthy volunteers. Single doses of 50, 100, 175, 300, 450, and 600 mg, or 10 days of repeated dosing were compared to placebo. Besides sa
COMMENT A PET ligand that reveals oxidative stress in the human brain will facilitate work within the AD research field on a number of levels. It will help investigators get a glimpse into oxidative stress in the brains of AD patients. From there, investigators c
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