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Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.

Nat Commun. 2025 Mar 10;16(1):2368. PubMed.

PAPER Tang M, Rong D, Gao X, Lu G, Tang H, Wang P, Shao NY, Xia D, Feng XH, He WF, Chen W, Lu JH, Liu W, Shen HM

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy.

Cell Discov. 2025 Mar 11;11(1):22. PubMed.

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Insulin resistance in Alzheimer's disease: signalling mechanisms and therapeutics strategies.

Inflammopharmacology. 2025 Mar 10; Epub 2025 Mar 10 PubMed.

PAPER Qaisar R, Karim A, Iqbal MS, Alkahtani SA, Ahmad F

Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.

Acta Neurol Belg. 2025 Mar 11; Epub 2025 Mar 11 PubMed.

PAPER Xiao Y, Zhang M, Lu N

Fluorescent Fingerprint Identification of Protein Structural Changes and Disease-Specific Amyloid Beta Aggregates Based on a Single-Nanozyme Sensor Array.

Anal Chem. 2025 Mar 11;97(9):4978-4986. Epub 2025 Feb 25 PubMed.

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Langmuir. 2025 Mar 11;41(9):5870-5876. Epub 2025 Feb 24 PubMed.

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Robert Mach on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I congratulate the authors for trying to develop an alternative strategy to imaging reactive oxygen and reactive nitrogen species (ROS/RNS) in vivo with PET. Our group developed the radiotracer, [18F]ROStrace, and we have conducted PET imaging studies to

PAPER Gallagher E, Li S, Lee H, Xu H, Lee VMY, Mach RH, McManus MJ

Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace

Int. J. Mol. Sci. 2025 . International Journal of Molecular Sciences

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THERAPEUTICS Inhibikase Therapeutics, Inc. IkT-148009 Small Molecule alpha-synuclein Other Between February 2021 and January 2023, Inhibikase ran a Phase 1 single- and multiple-ascending-dose trial. The study enrolled 108 participants, and tested nine single doses fro

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THERAPEUTICS Coya Therapeutics IL2 plus Abatacept Combination Other Inflammation In October 2021, an investigator-initiated, open-label study of COYA 302 began at the Houston Methodist Research Institute. The study planned to enroll 10 people with ALS, treat them ever

Giulia Albertini

VIB/KU Leuven
Belgium

PAPER Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.

bioRxiv. 2025 Feb 20; PubMed.

PAPER Sharma V, Unjum Saqib BZ, Aran KR

Leptin as a potential neuroprotective target in Parkinson's Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration.

Neuroscience. 2025 Mar 8;572:134-144. Epub 2025 Mar 8 PubMed.

PAPER Jiang Y, Jin J, Piao Y, Yin Y, Tang L, Guan Q, Gao Y, Feng T, Wang Z

A simple and effective screening strategy for early multiple system atrophy diagnosis and α-Synuclein forms in erythrocytes.

Front Aging Neurosci. 2025;17:1533504. Epub 2025 Feb 21 PubMed.