A Hyeon Lee

Korea Brain Research Institute
, Korea, Republic of

Kaitlin Casaletto on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This paper is a massive accomplishment, representing the most robust evidence yet of female-specific vulnerability to tau aggregation. Applying a meta-analytic approach, the authors pooled estimates across six studies, including more than 1,300 participan

Pierre Tariot on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex

Confirmed: Women Accumulate Tangles Faster Than Do Men

RESEARCH NEWS 2025-03-12 Research News Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the strongest evidence yet. In the March 3 JAM

Nicolai Franzmeier, Davina Biel on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This meta-analysis by Coughlan et al. provides robust evidence across six longitudinal cohorts, showing that women accumulate tau pathology faster than men in preclinical AD. This work is of high clinical relevance, as the transition from amyloidosis to t

PAPER Xu X, Kwon J, Yan R, Apio C, Song S, Heo G, Yang Q, Timsina J, Liu M, Budde J, Blennow K, Zetterberg H, Lleó A, Ruiz A, Molinuevo JL, Lee VM, Deming Y, Heslegrave AJ, Hohman TJ, Pastor P, Peskind ER, Albert MS, Morris JC, Park T, Cruchaga C, Sung YJ

Sex Differences in Apolipoprotein E and Alzheimer Disease Pathology Across Ancestries.

JAMA Netw Open. 2025 Mar 3;8(3):e250562. PubMed.

Masoud Ghamari-Langroudi

United States

Meagan McManus on A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

COMMENT I commend the authors for their exceptional characterization of the novel PET probe [18F]FEDV, which shows strong potential for detecting reactive oxygen species (ROS) in models of stroke and tauopathy. The validation of [18F]FEDV using dihydroethidium, t